HitPredict

Interactor 1: O44490 (O44490)
ELKS/RAB6-interacting/CAST family member 2
Gene: elks-1

Interactor 2: LIPA (Q21049)
Liprin-alpha (LAR-interacting protein alpha) (Synapse defective protein 2)
Gene: syd-2

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	19286562, 24322429, 34416233, 35933017
Identification Methods	enzymatic study, two hybrid, affinity chromatography technology, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007274 - neuromuscular synaptic transmission GO:0008104 - protein localization GO:0048786 - presynaptic active zone
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 836 Ce			1 1139
+	Ce
		219234 O44490_CAEEL (1-836): 2.84e-48: 186: 100.00		LIPB_CAEEL (384-1109): 3.5e-76: 274: 16.60
+	Dm
		1303379 MYSN_DROME (258-833): 7.23e-23: 107: 10.66		MYSN_DROME (1-630): 9.43e-27: 120: 11.90
+	Hs
		528432 MYH13_HUMAN (7-788): 1.05e-31: 135: 10.57		MYH8_HUMAN (451-1039): 3.43e-17: 89.8: 8.57
+	Hs
		724686 MYH9_HUMAN (7-780): 4.82e-32: 137: 7.53		MYH9_HUMAN (1-384): 1.68e-14: 81: 12.37
+	Hs
		528356 MYH6_HUMAN (17-777): 6.44e-30: 130: 8.61		MYH6_HUMAN (500-974): 1.17e-12: 74.8: 7.69
+	Hs
		724687 MYH9_HUMAN (7-780): 4.82e-32: 137: 7.53		MYH10_HUMAN (597-1001): 2.47e-09: 64: 7.66
+	Hs
		502933 MYH3_HUMAN (285-836): 1.6e-24: 112: 11.73		MYH4_HUMAN (451-1039): 6.14e-16: 85.6: 7.59
+	Hs
		502901 MYH3_HUMAN (285-836): 1.6e-24: 112: 11.73		MYH6_HUMAN (500-974): 1.17e-12: 74.8: 7.69
+	Hs
		724895 MYH14_HUMAN (1-769): 2.38e-21: 102: 8.56		MYH9_HUMAN (1-384): 1.68e-14: 81: 12.37
+	Hs
		522657 MYH7_HUMAN (9-589): 3.26e-19: 95.5: 7.99		MYH4_HUMAN (451-1039): 6.14e-16: 85.6: 7.59
+	Hs
		528435 MYH4_HUMAN (7-554): 3.47e-17: 89: 8.48		MYH8_HUMAN (451-1039): 3.43e-17: 89.8: 8.57
+	Rn
		361106 MYH6_RAT (7-524): 8.84e-20: 97.4: 9.92		MYH6_RAT (500-952): 2.45e-12: 74: 7.41
+	Hs
		166822 ERC2_HUMAN (56-685): 4.48e-21: 101: 10.30		LIPA4_HUMAN (446-916): 2.98e-10: 66.7: 9.90
+	Hs
		725189 MYH14_HUMAN (1-769): 2.38e-21: 102: 8.56		MYH10_HUMAN (597-1001): 2.47e-09: 64: 7.66
+	Hs
		166821 ERC2_HUMAN (56-685): 4.48e-21: 101: 10.30		LIPA2_HUMAN (5-373): 1.17e-09: 64.8: 11.83
+	Hs
		166833 ERC2_HUMAN (56-685): 4.48e-21: 101: 10.30		LIPA1_HUMAN (1-435): 2.01e-09: 64: 11.72
+	Hs
		166819 ERC2_HUMAN (56-685): 4.48e-21: 101: 10.30		LIPA3_HUMAN (1-428): 6.64e-09: 62.5: 12.15
+	Hs
		725097 MYH11_HUMAN (4-458): 7.77e-15: 81.3: 8.10		MYH10_HUMAN (597-1001): 2.47e-09: 64: 7.66