HitPredict

Interactor 1: O45430 (O45430)
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
Gene: mccc-1

Interactor 2: SIR42 (Q20481)
NAD-dependent protein deacylase sir-2.3 (EC 2.3.1.286) (Regulatory protein SIR2 homolog 3)
Gene: sir-2.3

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23438705
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 671 Ce			1 287
+	Ce
		220020 O45430_CAEEL (1-671): 0: 669: 100.00		SIR41_CAEEL (1-287): 4.53e-124: 357: 75.26
+	Hs
		1301307 MCCA_HUMAN (5-670): 0: 662: 51.10		SIR4_HUMAN (5-287): 1.16e-120: 349: 42.40
+	Hs
		398317 PCCA_HUMAN (1-670): 0: 620: 38.90		SIR4_HUMAN (5-287): 1.16e-120: 349: 42.40
+	Ce
		1090968 PCCA_CAEEL (10-670): 0: 587: 41.05		SIR41_CAEEL (1-287): 4.53e-124: 357: 75.26
+	Ce
		1090969 PCCA_CAEEL (10-670): 0: 587: 41.05		SIR42_CAEEL (1-287): 7.95e-123: 354: 100.00
+	Hs
		1024071 ACACA_HUMAN (5-670): 0: 571: 24.60		SIR1_HUMAN (13-287): 2.16e-86: 275: 20.29
+	Mm
		1131968 ACACA_MOUSE (5-670): 0: 569: 24.46		SIR1_MOUSE (13-287): 1.31e-85: 272: 20.29
+	Hs
		1024048 ACACA_HUMAN (5-670): 0: 571: 24.60		SIR6_HUMAN (8-287): 3.22e-82: 253: 23.68
+	Hs
		1024102 ACACA_HUMAN (5-670): 0: 571: 24.60		SIR7_HUMAN (3-287): 5.57e-73: 231: 22.79
+	Hs
		653316 PYR1_HUMAN (5-419): 8.1e-49: 187: 15.22		SIR6_HUMAN (8-287): 3.22e-82: 253: 23.68
+	Ce
		184868 PYC1_CAEEL (493-670): 2.77e-12: 72.5: 20.23		SIR41_CAEEL (1-287): 4.53e-124: 357: 75.26
+	Ce
		184869 PYC1_CAEEL (493-670): 2.77e-12: 72.5: 20.23		SIR42_CAEEL (1-287): 7.95e-123: 354: 100.00
+	Hs
		653389 PYR1_HUMAN (5-419): 8.1e-49: 187: 15.22		SIR7_HUMAN (3-287): 5.57e-73: 231: 22.79
+	Hs
		513653 PYC_HUMAN (597-670): 7.17e-11: 67.9: 28.38		SIR4_HUMAN (5-287): 1.16e-120: 349: 42.40