HitPredict

Interactor 1: NHR4 (O45436)
Nuclear hormone receptor family member nhr-4
Gene: nhr-4

Interactor 2: PMK1 (Q17446)
Mitogen-activated protein kinase pmk-1 (EC 2.7.11.24) (Stress-activated protein kinase pmk-1) (p38 MAP kinase 1)
Gene: pmk-1

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	14704431
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 492 Ce			1 377
+	Hs
		625224 NR2C2_HUMAN (42-486): 2.01e-100: 315: 19.34		CDK2_HUMAN (32-327): 4.17e-147: 419: 35.10
+	Hs
		369006 ESR1_HUMAN (15-492): 1.68e-77: 255: 18.89		CDK2_HUMAN (32-327): 4.17e-147: 419: 35.10
+	Hs
		960086 PPARA_HUMAN (8-481): 7.56e-81: 260: 15.76		CDK3_HUMAN (32-338): 5.48e-140: 401: 35.46
+	Hs
		369038 ESR1_HUMAN (15-492): 1.68e-77: 255: 18.89		MK01_HUMAN (24-361): 6.4e-134: 388: 45.80
+	Hs
		509906 VDR_HUMAN (28-483): 3.87e-79: 254: 17.25		MK03_HUMAN (24-361): 3.5e-134: 389: 44.64
+	Hs
		509908 VDR_HUMAN (28-483): 3.87e-79: 254: 17.25		MK01_HUMAN (24-361): 6.4e-134: 388: 45.80
+	Hs
		658821 PPARG_HUMAN (19-480): 6.74e-78: 254: 14.47		MK01_HUMAN (24-361): 6.4e-134: 388: 45.80
+	Hs
		265865 NR1I2_HUMAN (27-481): 9.25e-71: 233: 18.70		MK07_HUMAN (21-373): 1.5e-133: 402: 40.88
+	Hs
		740456 PPARG_HUMAN (19-480): 6.74e-78: 254: 14.47		MK09_HUMAN (19-371): 3.25e-106: 320: 45.70
+	Hs
		647494 HNF4A_HUMAN (28-161): 1.98e-30: 125: 45.52		MK03_HUMAN (24-361): 3.5e-134: 389: 44.64
+	Hs
		658827 HNF4A_HUMAN (28-161): 1.98e-30: 125: 45.52		MK01_HUMAN (24-361): 6.4e-134: 388: 45.80
+	Hs
		782498 HNF4A_HUMAN (28-161): 1.98e-30: 125: 45.52		MK08_HUMAN (19-361): 2.23e-103: 313: 45.68