HitPredict

Interactor 1: NHR49 (O45666)
Nuclear hormone receptor family member nhr-49
Gene: nhr-49

Interactor 2: NHR19 (Q09528)
Nuclear hormone receptor family member nhr-19
Gene: nhr-19

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.904

Property	Details
Experiments	19123269, 23791784, 22511885, 14704431
Identification Methods	two hybrid, two hybrid array, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Hormone_recep~Hormone_recep, Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 501 Ce			1 477
+	Ce
		184366 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		O17081_CAEEL (73-476): 4.97e-96: 297: 25.25
+	Ce
		220347 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q95Y05_CAEEL (41-476): 3.09e-95: 295: 22.94
+	Ce
		220324 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		P90822_CAEEL (64-476): 7.44e-93: 288: 20.96
+	Ce
		220319 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR49_CAEEL (74-476): 1.12e-90: 286: 22.89
+	Ce
		220345 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR80_CAEEL (72-474): 2.48e-89: 283: 21.19
+	Ce
		106951 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NH114_CAEEL (66-476): 8.85e-90: 281: 23.54
+	Ce
		220344 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q86PJ4_CAEEL (41-476): 2.27e-89: 280: 27.13
+	Ce
		220341 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q3LQX0_CAEEL (41-476): 4.75e-86: 272: 27.35
+	Hs
		368969 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		ESR1_HUMAN (5-474): 5.8e-99: 311: 19.67
+	Hs
		782496 HNF4A_HUMAN (5-495): 7.48e-107: 328: 27.80		HNF4A_HUMAN (57-476): 2.05e-95: 297: 24.41
+	Mm
		509288 RXRA_MOUSE (1-423): 7.87e-106: 325: 27.66		RARA_MOUSE (1-476): 2.19e-94: 295: 18.60
+	Hs
		487899 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		RARA_HUMAN (1-476): 2.32e-94: 294: 18.80
+	Mm
		659690 RXRA_MOUSE (1-423): 7.87e-106: 325: 27.66		NR1H3_MOUSE (52-473): 6.01e-89: 280: 17.93
+	Ce
		106935 H2KZA1_CAEEL (14-483): 6.33e-103: 322: 28.78		NH114_CAEEL (66-476): 8.85e-90: 281: 23.54
+	Hs
		490049 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		NR2F6_HUMAN (47-476): 1.57e-87: 275: 21.86
+	Ce
		220320 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		O45987_CAEEL (68-474): 6.26e-28: 115: 23.78
+	Ce
		183829 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		O16346_CAEEL (80-476): 3.41e-24: 105: 25.61
+	Ce
		184316 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		O17013_CAEEL (48-475): 1.97e-23: 103: 23.04
+	Ce
		220343 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q86PI8_CAEEL (68-176): 7.24e-21: 94.7: 40.34
+	Ce
		220349 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR71_CAEEL (252-474): 3.35e-11: 67.4: 23.24