HitPredict

Interactor 1: NHR49 (O45666)
Nuclear hormone receptor family member nhr-49
Gene: nhr-49

Interactor 2: Q20097 (Q20097)
Nuclear Hormone Receptor family
Gene: nhr-78

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	23791784
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Hormone_recep~Hormone_recep, Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 501 Ce			1 401
+	Ce
		220328 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR22_CAEEL (3-395): 3.03e-119: 359: 31.60
+	Ce
		185183 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR79_CAEEL (2-394): 3.32e-111: 335: 28.98
+	Ce
		219559 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		O44577_CAEEL (2-394): 6.77e-109: 328: 27.97
+	Ce
		220340 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR11_CAEEL (3-395): 6.85e-108: 326: 29.48
+	Ce
		220345 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR80_CAEEL (2-395): 1.84e-100: 309: 24.61
+	Ce
		220327 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR20_CAEEL (2-395): 4.25e-93: 289: 23.09
+	Ce
		220319 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR49_CAEEL (2-396): 6.44e-92: 287: 18.74
+	Ce
		220347 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q95Y05_CAEEL (3-396): 2.28e-89: 277: 21.98
+	Ce
		220326 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR19_CAEEL (2-396): 7.17e-87: 273: 18.81
+	Ce
		106951 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NH114_CAEEL (3-394): 1.55e-82: 260: 20.29
+	Ce
		220352 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR13_CAEEL (14-395): 8.61e-81: 256: 30.38
+	Ce
		184366 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		O17081_CAEEL (2-396): 1.14e-78: 249: 19.15
+	Ce
		220342 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR76_CAEEL (2-393): 1.31e-74: 241: 21.92
+	Hs
		782496 HNF4A_HUMAN (5-495): 7.48e-107: 328: 27.80		HNF4A_HUMAN (3-401): 1.05e-92: 288: 17.79
+	Hs
		490049 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		NR2F6_HUMAN (1-401): 5.61e-89: 276: 15.96
+	Hs
		500354 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		RARB_HUMAN (2-398): 9.14e-85: 267: 17.13
+	Mm
		659690 RXRA_MOUSE (1-423): 7.87e-106: 325: 27.66		NR1H3_MOUSE (3-393): 1.45e-83: 263: 17.39
+	Hs
		368969 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		ESR1_HUMAN (3-397): 2.22e-82: 265: 15.16
+	Ce
		106935 H2KZA1_CAEEL (14-483): 6.33e-103: 322: 28.78		NH114_CAEEL (3-394): 1.55e-82: 260: 20.29
+	Ce
		220343 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q86PI8_CAEEL (3-277): 2.56e-14: 75.1: 26.40