HitPredict

Interactor 1: NHR49 (O45666)
Nuclear hormone receptor family member nhr-49
Gene: nhr-49

Interactor 2: NHR11 (Q23294)
Nuclear hormone receptor family member nhr-11
Gene: nhr-11

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.59	1.00	0.768

Property	Details
Experiments	23791784, 22511885
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Hormone_recep~Hormone_recep, Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms	GO:0005634 - nucleus GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 501 Ce			1 459
+	Ce
		220328 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR22_CAEEL (5-458): 2.19e-88: 282: 33.88
+	Ce
		220352 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR13_CAEEL (17-457): 2.54e-84: 267: 31.84
+	Ce
		220319 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR49_CAEEL (1-457): 2.29e-81: 261: 16.78
+	Ce
		185183 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR79_CAEEL (5-459): 3.22e-81: 260: 31.49
+	Ce
		106951 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NH114_CAEEL (2-457): 9.48e-80: 255: 18.34
+	Ce
		220327 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR20_CAEEL (2-456): 5.61e-78: 251: 21.26
+	Ce
		220326 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR19_CAEEL (5-455): 1.21e-76: 249: 18.64
+	Ce
		220343 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q86PI8_CAEEL (4-318): 3.84e-79: 249: 22.81
+	Ce
		219559 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		O44577_CAEEL (5-459): 5.1e-77: 248: 28.73
+	Ce
		220334 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q20097_CAEEL (5-456): 3.88e-77: 247: 27.91
+	Ce
		220349 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR71_CAEEL (2-455): 4.18e-74: 245: 17.90
+	Ce
		220345 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR80_CAEEL (2-456): 1.8e-73: 241: 21.91
+	Ce
		109537 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR66_CAEEL (3-458): 4.56e-70: 237: 18.91
+	Ce
		220357 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NH121_CAEEL (5-455): 6.65e-71: 233: 20.61
+	Ce
		220342 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR76_CAEEL (5-454): 4.34e-55: 192: 17.32
+	Ce
		220347 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q95Y05_CAEEL (5-455): 2.21e-49: 175: 17.14
+	Hs
		509917 HNF4A_HUMAN (5-495): 7.48e-107: 328: 27.80		VDR_HUMAN (1-455): 6.88e-71: 232: 14.16
+	Ce
		184860 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NH169_CAEEL (3-119): 2.12e-16: 82.4: 35.82
+	Ce
		220087 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		O45507_CAEEL (5-85): 1.42e-13: 73.6: 44.05
+	Ce
		220353 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q9NAJ3_CAEEL (5-83): 1.52e-13: 73.6: 43.04