HitPredict

Interactor 1: NHR49 (O45666)
Nuclear hormone receptor family member nhr-49
Gene: nhr-49

Interactor 2: Q86PJ4 (Q86PJ4)
Nuclear Hormone Receptor family (Nuclear receptor NHR-105)
Gene: nhr-105

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.53	1.00	0.730

Property	Details
Experiments	14704431, 23791784
Identification Methods	two hybrid pooling approach, two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Hormone_recep~Hormone_recep, Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 501 Ce			1 429
+	Ce
		220341 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q3LQX0_CAEEL (1-429): 5.37e-114: 341: 93.94
+	Ce
		220319 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR49_CAEEL (14-428): 1.79e-87: 276: 19.73
+	Ce
		184366 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		O17081_CAEEL (38-424): 1.7e-88: 275: 22.74
+	Ce
		220326 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR19_CAEEL (13-425): 2.16e-87: 275: 26.39
+	Ce
		220347 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q95Y05_CAEEL (1-424): 3.49e-85: 268: 22.02
+	Ce
		183829 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		O16346_CAEEL (38-424): 2.32e-84: 265: 23.76
+	Ce
		220324 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		P90822_CAEEL (22-423): 7.25e-84: 263: 21.92
+	Ce
		106951 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NH114_CAEEL (25-429): 3.66e-83: 262: 19.77
+	Ce
		220320 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		O45987_CAEEL (26-422): 9.27e-80: 251: 22.42
+	Hs
		587112 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		RXRA_HUMAN (4-422): 6.36e-100: 307: 16.47
+	Hs
		782496 HNF4A_HUMAN (5-495): 7.48e-107: 328: 27.80		HNF4A_HUMAN (2-424): 1.08e-96: 299: 19.15
+	Hs
		587136 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		RXRG_HUMAN (9-422): 2.74e-98: 303: 15.46
+	Hs
		368969 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		ESR1_HUMAN (3-422): 3.83e-93: 294: 15.88
+	Hs
		587162 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		NR1H3_HUMAN (1-421): 6.04e-88: 276: 16.87
+	Mm
		659690 RXRA_MOUSE (1-423): 7.87e-106: 325: 27.66		NR1H3_MOUSE (11-421): 1.37e-85: 270: 16.79
+	Hs
		490049 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		NR2F6_HUMAN (13-424): 6.22e-86: 269: 16.71
+	Hs
		587117 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		NR4A1_HUMAN (6-427): 5.38e-83: 267: 17.54
+	Ce
		106935 H2KZA1_CAEEL (14-483): 6.33e-103: 322: 28.78		NH114_CAEEL (25-429): 3.66e-83: 262: 19.77
+	Ce
		220343 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q86PI8_CAEEL (38-147): 3.68e-20: 92: 41.74
+	Ce
		109537 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR66_CAEEL (24-415): 3.45e-18: 89: 24.22