HitPredict

Interactor 1: CTBP (O46036)
C-terminal-binding protein (CtBP protein) (dCtBP)
Gene: CTBP

Interactor 2: KNIR (P10734)
Zygotic gap protein knirps (Nuclear receptor subfamily 0 group A member 1)
Gene: kni

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.740

Property	Details
Experiments	9525852, 17972097, 30995488, 14605208, 19805071, unassigned4
Identification Methods	affinity chromatography technology, pull down, two hybrid, anti tag coimmunoprecipitation, miniaturized immunoprecipitation, experimental interaction detection
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0045892 - negative regulation of DNA-templated transcription GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 476 Dm			1 429
+	Dm
		220621 CTBP_DROME (1-476): 0: 574: 100.00		EGON_DROME (1-341): 2.09e-70: 228: 33.85
+	Dm
		220623 CTBP_DROME (1-476): 0: 574: 100.00		TLL_DROME (2-193): 3.6e-59: 201: 27.72
+	Dm
		220639 CTBP_DROME (1-476): 0: 574: 100.00		HR78_DROME (3-264): 1.1e-56: 198: 20.91
+	Dm
		220617 CTBP_DROME (1-476): 0: 574: 100.00		KNRL_DROME (1-91): 2.9e-44: 165: 87.91
+	Hs
		369269 CTBP2_HUMAN (14-457): 1.42e-166: 478: 62.02		ESR1_HUMAN (3-179): 3.52e-49: 178: 29.94
+	Hs
		369538 CTBP1_HUMAN (1-456): 3.08e-165: 475: 60.31		ESR1_HUMAN (3-179): 3.52e-49: 178: 29.94
+	Mm
		292168 CTBP1_MOUSE (1-456): 3.64e-166: 477: 60.97		ERR2_MOUSE (3-187): 8.19e-48: 170: 24.49
+	Hs
		197175 SERA_HUMAN (28-439): 8.78e-136: 403: 25.48		ESR1_HUMAN (3-179): 3.52e-49: 178: 29.94
+	Hs
		881244 CTBP2_HUMAN (14-457): 1.42e-166: 478: 62.02		ESR2_HUMAN (5-105): 6.83e-17: 84.7: 42.73
+	Hs
		1032535 CTBP1_HUMAN (1-456): 3.08e-165: 475: 60.31		ESR2_HUMAN (5-105): 6.83e-17: 84.7: 42.73