HitPredict

Interactor 1: PIAS3 (O54714)
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)
Gene: PIAS3

Interactor 2: SUMO1 (P63166)
Small ubiquitin-related modifier 1 (SUMO-1) (SMT3 homolog 3) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C)
Gene: SUMO1

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	12387893
Identification Methods	two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Rad60-SLD~zf-MIZ
Common GO terms	GO:0005634 - nucleus GO:0015459 - potassium channel regulator activity GO:0016607 - nuclear speck GO:0016925 - protein sumoylation GO:0030425 - dendrite
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 628 Mm			1 101
+	Hs
		928241 PIAS3_HUMAN (1-628): 0: 706: 96.98		SUMO1_HUMAN (1-101): 1.01e-41: 134: 100.00
+	Hs
		902827 PIAS3_HUMAN (1-628): 0: 706: 96.98		SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36
+	Hs
		879167 PIAS3_HUMAN (1-628): 0: 706: 96.98		SUMO3_HUMAN (1-97): 1.65e-37: 123: 47.42
+	Hs
		278040 PIAS1_HUMAN (1-628): 0: 558: 56.54		SUMO1_HUMAN (1-101): 1.01e-41: 134: 100.00
+	Hs
		102146 PIAS1_HUMAN (1-628): 0: 558: 56.54		SUMO5_HUMAN (1-101): 4.52e-41: 132: 88.12
+	Hs
		278020 PIAS1_HUMAN (1-628): 0: 558: 56.54		SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36
+	Hs
		278009 PIAS1_HUMAN (1-628): 0: 558: 56.54		SUMO3_HUMAN (1-97): 1.65e-37: 123: 47.42
+	Hs
		278256 PIAS2_HUMAN (1-550): 0: 546: 56.70		SUMO1_HUMAN (1-101): 1.01e-41: 134: 100.00
+	Hs
		102147 PIAS2_HUMAN (1-550): 0: 546: 56.70		SUMO5_HUMAN (1-101): 4.52e-41: 132: 88.12
+	Hs
		278253 PIAS2_HUMAN (1-550): 0: 546: 56.70		SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36
+	Hs
		278250 PIAS2_HUMAN (1-550): 0: 546: 56.70		SUMO3_HUMAN (1-97): 1.65e-37: 123: 47.42
+	Rn
		1140374 PIAS2_RAT (1-540): 0: 530: 56.47		SUMO3_RAT (1-100): 1.5e-39: 128: 46.00
+	Hs
		928135 PIAS4_HUMAN (2-477): 2.69e-156: 460: 45.46		SUMO1_HUMAN (1-101): 1.01e-41: 134: 100.00
+	At
		1147334 SIZ1_ARATH (5-623): 6.71e-155: 469: 20.41		SUMO2_ARATH (6-99): 5.11e-38: 124: 45.75
+	At
		1147333 SIZ1_ARATH (5-623): 6.71e-155: 469: 20.41		SUMO3_ARATH (6-97): 1.88e-37: 123: 38.04
+	Rn
		78199 B5DFF9_RAT (2-477): 5.52e-153: 452: 45.11		SUMO1_RAT (1-101): 1.01e-41: 134: 100.00
+	At
		878961 SIZ1_ARATH (5-623): 6.71e-155: 469: 20.41		SUMO1_ARATH (9-95): 3e-35: 117: 47.13
+	Hs
		902668 PIAS4_HUMAN (2-477): 2.69e-156: 460: 45.46		SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36
+	Hs
		879136 PIAS4_HUMAN (2-477): 2.69e-156: 460: 45.46		SUMO3_HUMAN (1-97): 1.65e-37: 123: 47.42
+	Rn
		78200 B5DFF9_RAT (2-477): 5.52e-153: 452: 45.11		SUMO3_RAT (1-100): 1.5e-39: 128: 46.00