HitPredict

Interactor 1: SUV91 (O54864)
Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Position-effect variegation 3-9 homolog) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1)
Gene: Suv39h1

Interactor 2: Q9DCC5 (Q9DCC5)
Cbx3 protein (Chromobox 3)
Gene: Cbx3

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	28059589, 29795351
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Chromo~Chromo
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Mm			1 183
+	Mm
		222460 SUV91_MOUSE (1-412): 2.81e-159: 456: 100.00		CBX3_MOUSE (1-183): 4.67e-71: 214: 99.45
+	Hs
		203674 SUV91_HUMAN (1-412): 1.51e-157: 452: 95.39		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		1027262 SUV92_HUMAN (2-411): 5.69e-145: 420: 57.21		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Mm
		222467 SUV91_MOUSE (1-412): 2.81e-159: 456: 100.00		CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89
+	Hs
		203638 SUV91_HUMAN (1-412): 1.51e-157: 452: 95.39		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		203823 SUV91_HUMAN (1-412): 1.51e-157: 452: 95.39		V9HWG0_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Mm
		222462 SUV91_MOUSE (1-412): 2.81e-159: 456: 100.00		CBX1_MOUSE (36-180): 1.02e-53: 170: 71.33
+	Mm
		613035 SUV92_MOUSE (5-411): 7.26e-141: 412: 56.48		CBX3_MOUSE (1-183): 4.67e-71: 214: 99.45
+	Hs
		203662 SUV91_HUMAN (1-412): 1.51e-157: 452: 95.39		CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33
+	Hs
		1331984 SUV92_HUMAN (2-411): 5.69e-145: 420: 57.21		V9HWG0_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		800527 SUV92_HUMAN (2-411): 5.69e-145: 420: 57.21		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		203597 SUV91_HUMAN (1-412): 1.51e-157: 452: 95.39		SUV91_HUMAN (3-179): 4.73e-40: 141: 16.20
+	Hs
		949887 SUV92_HUMAN (2-411): 5.69e-145: 420: 57.21		CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33
+	Xl
		1155581 SUV91_XENLA (1-412): 6.16e-145: 420: 73.93		Q802A7_XENLA (14-178): 9.81e-53: 168: 64.07
+	Hs
		123140 SUV91_HUMAN (1-412): 1.51e-157: 452: 95.39		CBX4_HUMAN (21-121): 4.95e-27: 108: 29.52
+	Hs
		327863 SUV92_HUMAN (2-411): 5.69e-145: 420: 57.21		CBX7_HUMAN (21-181): 5.6e-29: 109: 22.78
+	Hs
		1027268 EHMT1_HUMAN (50-408): 2.67e-87: 290: 27.96		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		800530 EHMT1_HUMAN (50-408): 2.67e-87: 290: 27.96		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		949889 EHMT1_HUMAN (50-408): 2.67e-87: 290: 27.96		CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33
+	Hs
		203794 EHMT1_HUMAN (50-408): 2.67e-87: 290: 27.96		SUV91_HUMAN (3-179): 4.73e-40: 141: 16.20