HitPredict

Interactor 1: B2L11 (O54918)
Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death)
Gene: Bcl2l11

Interactor 2: B2LA1 (Q07440)
Bcl-2-related protein A1 (A1-A) (Hemopoietic-specific early response protein) (Protein BFL-1)
Gene: Bcl2a1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	15694340
Identification Methods	surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Bcl-2~Bclx_interact
Common GO terms	GO:0001782 - B cell homeostasis GO:0005737 - cytoplasm GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage GO:0043065 - positive regulation of apoptotic process GO:0097192 - extrinsic apoptotic signaling pathway in absence of ligand
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 196 Mm			1 172
+	Rn
		291714 B2L11_RAT (1-196): 1.25e-129: 364: 98.47		Q925A9_RAT (1-172): 1.73e-77: 230: 90.70
+	Hs
		206749 B2L11_HUMAN (1-196): 2.81e-117: 332: 86.50		B2LA1_HUMAN (1-172): 8.97e-75: 223: 72.09
+	Mm
		222623 B2L11_MOUSE (1-196): 9.57e-130: 364: 100.00		BCL2_MOUSE (24-163): 1.39e-40: 138: 27.14
+	Rn
		291711 B2L11_RAT (1-196): 1.25e-129: 364: 98.47		BCL2_RAT (24-163): 1.22e-40: 138: 27.14
+	Mm
		222627 B2L11_MOUSE (1-196): 9.57e-130: 364: 100.00		BAX_MOUSE (11-156): 4.23e-40: 136: 23.29
+	Rn
		291715 B2L11_RAT (1-196): 1.25e-129: 364: 98.47		MCL1_RAT (27-148): 3.87e-35: 126: 29.51
+	Rn
		291710 B2L11_RAT (1-196): 1.25e-129: 364: 98.47		O88996_RAT (24-149): 7.5e-35: 122: 22.22
+	Mm
		222625 B2L11_MOUSE (1-196): 9.57e-130: 364: 100.00		MCL1_MOUSE (27-148): 3.75e-33: 121: 27.05
+	Mm
		222630 B2L11_MOUSE (1-196): 9.57e-130: 364: 100.00		B2CL1_MOUSE (33-149): 8.81e-34: 121: 27.35
+	Rn
		291712 B2L11_RAT (1-196): 1.25e-129: 364: 98.47		B2CL1_RAT (33-149): 8.81e-34: 121: 27.35
+	Hs
		206738 B2L11_HUMAN (1-196): 2.81e-117: 332: 86.50		BAX_HUMAN (11-156): 4.7e-39: 133: 21.92
+	Hs
		206715 B2L11_HUMAN (1-196): 2.81e-117: 332: 86.50		BCL2_HUMAN (26-163): 6.4e-38: 131: 25.36
+	Hs
		206750 B2L11_HUMAN (1-196): 2.81e-117: 332: 86.50		BAK_HUMAN (17-150): 3.55e-36: 126: 24.44
+	Hs
		206740 B2L11_HUMAN (1-196): 2.81e-117: 332: 86.50		MCL1_HUMAN (27-148): 8.13e-34: 123: 27.87
+	Hs
		206739 B2L11_HUMAN (1-196): 2.81e-117: 332: 86.50		B2CL1_HUMAN (33-149): 5.32e-34: 121: 26.50
+	Hs
		206762 B2L11_HUMAN (1-196): 2.81e-117: 332: 86.50		B2CL2_HUMAN (24-149): 4.28e-34: 120: 22.22