HitPredict

Interactor 1: SOCS5 (O54928)
Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2-containing protein 5)
Gene: SOCS5

Interactor 2: CUL5 (Q9D5V5)
Cullin-5 (CUL-5)
Gene: CUL5

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19385048
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 536 Mm			1 780
+	Hs
		256856 SOCS5_HUMAN (1-536): 0: 678: 94.40		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		1265273 SOCS4_MOUSE (103-529): 2.83e-132: 393: 52.44		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		1263831 SOCS4_HUMAN (103-530): 1.05e-129: 386: 53.47		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		1322060 SOCS6_MOUSE (105-519): 6.13e-97: 306: 22.57		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		147544 SOCS6_HUMAN (95-519): 9.45e-78: 255: 21.30		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Hs
		146642 SOCS2_HUMAN (340-520): 8.26e-52: 177: 29.53		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		193366 SOCS2_MOUSE (340-520): 8.38e-51: 174: 29.53		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Mm
		1257617 SOCS7_MOUSE (303-525): 3.46e-40: 155: 20.59		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Mm
		193357 SOCS1_MOUSE (365-520): 1.41e-42: 153: 25.00		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		146692 SOCS7_HUMAN (303-525): 6.3e-40: 154: 20.59		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Hs
		181885 SOCS1_HUMAN (365-520): 3.1e-43: 154: 25.00		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		1143676 CISH_MOUSE (327-520): 2.29e-40: 148: 23.81		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		1274062 CISH_HUMAN (297-520): 1.14e-39: 146: 21.37		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Hs
		146625 SOCS2_HUMAN (340-520): 8.26e-52: 177: 29.53		CUL4A_HUMAN (16-780): 0: 733: 24.61
+	Hs
		1041644 SHB_HUMAN (233-487): 1.46e-43: 163: 14.90		CUL3_HUMAN (8-780): 0: 743: 22.71
+	Hs
		1042817 VAV3_HUMAN (267-480): 9.14e-40: 156: 18.39		CUL3_HUMAN (8-780): 0: 743: 22.71
+	Hs
		855795 VAV2_HUMAN (278-480): 6.05e-39: 153: 16.67		CUL4A_HUMAN (16-780): 0: 733: 24.61
+	Hs
		147421 SOCS3_HUMAN (369-517): 1.51e-34: 131: 22.63		CUL4B_HUMAN (16-780): 0: 726: 25.52
+	Hs
		181856 SOCS1_HUMAN (365-520): 3.1e-43: 154: 25.00		CUL2_HUMAN (10-780): 0: 688: 26.37
+	Hs
		1041477 CISH_HUMAN (297-520): 1.14e-39: 146: 21.37		CUL2_HUMAN (10-780): 0: 688: 26.37