HitPredict

Interactor 1: SEM6B (O54951)
Semaphorin-6B (Semaphorin VIB) (Sema VIB) (Semaphorin-N) (Sema N)
Gene: Sema6b

Interactor 2: PLXA2 (P70207)
Plexin-A2 (Plex 2) (Plexin-2)
Gene: Plxna2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	26633812
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PSI~Sema, PSI~TIG, PSI~TIG_2, PSI~TIG_plexin, Sema~Sema, Sema~TIG, Sema~TIG_plexin
Common GO terms	GO:0005886 - plasma membrane GO:0071526 - semaphorin-plexin signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 886 Mm			1 1894
+	Mm
		192795 SEM6A_MOUSE (10-886): 0: 671: 40.81		PLXA2_MOUSE (1-1894): 0: 2671: 100.00
+	Mm
		936311 SEM3D_MOUSE (10-670): 0: 635: 24.42		PLXA2_MOUSE (1-1894): 0: 2671: 100.00
+	Mm
		936310 SEM6D_MOUSE (12-591): 0: 598: 50.77		PLXA2_MOUSE (1-1894): 0: 2671: 100.00
+	Mm
		222745 SEM6B_MOUSE (1-886): 0: 748: 100.00		PLXA4_MOUSE (3-1894): 0: 2509: 66.72
+	Mm
		139669 SEM3A_MOUSE (9-673): 0: 672: 25.29		PLXA4_MOUSE (3-1894): 0: 2509: 66.72
+	Mm
		192797 SEM6A_MOUSE (10-886): 0: 671: 40.81		PLXA4_MOUSE (3-1894): 0: 2509: 66.72
+	Mm
		1176226 SEM6D_MOUSE (12-591): 0: 598: 50.77		PLXA4_MOUSE (3-1894): 0: 2509: 66.72
+	Mm
		192794 SEM6A_MOUSE (10-886): 0: 671: 40.81		PLXA1_MOUSE (23-1894): 0: 2431: 63.11
+	Mm
		936300 SEM6D_MOUSE (12-591): 0: 598: 50.77		PLXA1_MOUSE (23-1894): 0: 2431: 63.11
+	Mm
		936315 SEM6D_MOUSE (12-591): 0: 598: 50.77		PLXA3_MOUSE (17-1894): 0: 2429: 59.09
+	Mm
		140342 SEM4D_MOUSE (18-882): 0: 576: 22.82		PLXB3_MOUSE (42-1891): 0: 1981: 33.40
+	Mm
		1112528 SEM3D_MOUSE (10-670): 0: 635: 24.42		PLXD1_MOUSE (45-1891): 0: 1859: 31.35
+	Mm
		71301 SEM4D_MOUSE (18-882): 0: 576: 22.82		PLXB2_MOUSE (35-1891): 0: 1907: 31.94
+	Mm
		936364 SEM3E_MOUSE (39-736): 0: 610: 25.14		PLXD1_MOUSE (45-1891): 0: 1859: 31.35
+	Hs
		165342 SEM3E_HUMAN (37-663): 0: 610: 27.74		PLXD1_HUMAN (45-1891): 0: 1825: 31.32
+	Mm
		139662 SEM3A_MOUSE (9-673): 0: 672: 25.29		SEM3A_MOUSE (40-553): 1.23e-126: 419: 14.79
+	Hs
		1055532 SEM3C_HUMAN (35-663): 0: 605: 25.46		SEM3A_HUMAN (40-553): 5.03e-126: 417: 14.97
+	Hs
		303598 SEM3C_HUMAN (35-663): 0: 605: 25.46		SEM3D_HUMAN (41-539): 1.39e-121: 405: 17.66
+	Mm
		1176229 SEM6D_MOUSE (12-591): 0: 598: 50.77		PLXC1_MOUSE (62-912): 1.17e-100: 360: 17.43
+	Mm
		140341 SEM4D_MOUSE (18-882): 0: 576: 22.82		PLXB1_MOUSE (548-866): 3.74e-12: 74: 16.47