HitPredict

Interactor 1: ACK1 (O54967)
Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2)
Gene: Tnk2

Interactor 2: MPRIP (P97434)
Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (RIP3) (p116Rip)
Gene: MPRIP

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29254152
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_9
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1055 Mm			1 1024
+	Mm
		222882 ACK1_MOUSE (1-1055): 0: 865: 100.00		MY18A_MOUSE (492-1024): 6.71e-26: 118: 12.96
+	Hs
		411772 LCK_HUMAN (1-398): 3.4e-128: 401: 30.33		MPRIP_HUMAN (1-1023): 0: 578: 91.33
+	Mm
		222845 ACK1_MOUSE (1-1055): 0: 865: 100.00		MYH10_MOUSE (511-1024): 6.22e-20: 98.3: 9.63
+	Mm
		222875 ACK1_MOUSE (1-1055): 0: 865: 100.00		MYH9_MOUSE (658-1018): 7.32e-13: 75.3: 13.22
+	Hs
		338585 EGFR_HUMAN (105-387): 1.28e-52: 203: 38.87		MPRIP_HUMAN (1-1023): 0: 578: 91.33
+	Hs
		411908 LCK_HUMAN (1-398): 3.4e-128: 401: 30.33		MRCKB_HUMAN (692-1024): 1.3e-20: 100: 13.35
+	Hs
		523231 SRC_HUMAN (1-400): 1.7e-127: 400: 31.42		MYH4_HUMAN (316-951): 9.3e-20: 98: 10.50
+	Hs
		412287 FYN_HUMAN (1-400): 2.25e-129: 405: 30.94		MY18A_HUMAN (590-1018): 1.2e-17: 91: 9.79
+	Hs
		983688 FAK1_HUMAN (6-718): 6.3e-131: 425: 21.35		SWP70_HUMAN (720-953): 2.76e-09: 63.1: 20.51
+	Hs
		111443 J3QRU1_HUMAN (1-400): 6.39e-131: 410: 30.18		MYH9_HUMAN (670-1018): 2.79e-13: 76.9: 12.82
+	Hs
		433272 YES_HUMAN (1-400): 5.47e-131: 410: 30.18		MYH9_HUMAN (670-1018): 2.79e-13: 76.9: 12.82
+	Hs
		412058 FYN_HUMAN (1-400): 2.25e-129: 405: 30.94		MYH9_HUMAN (670-1018): 2.79e-13: 76.9: 12.82
+	Hs
		411758 LCK_HUMAN (1-398): 3.4e-128: 401: 30.33		MRCKA_HUMAN (806-1024): 7.38e-12: 72.1: 10.67
+	Hs
		412320 FYN_HUMAN (1-400): 2.25e-129: 405: 30.94		CK5P2_HUMAN (677-993): 4.34e-09: 62.9: 20.12
+	Hs
		665375 EPHA3_HUMAN (69-493): 1.79e-116: 384: 26.57		MYH9_HUMAN (670-1018): 2.79e-13: 76.9: 12.82
+	Hs
		434101 LYN_HUMAN (85-387): 1.5e-107: 347: 36.07		MRCKB_HUMAN (692-1024): 1.3e-20: 100: 13.35
+	Hs
		433620 LYN_HUMAN (85-387): 1.5e-107: 347: 36.07		MYH9_HUMAN (670-1018): 2.79e-13: 76.9: 12.82
+	Hs
		433818 LYN_HUMAN (85-387): 1.5e-107: 347: 36.07		MRCKA_HUMAN (806-1024): 7.38e-12: 72.1: 10.67
+	Hs
		254427 EGFR_HUMAN (105-387): 1.28e-52: 203: 38.87		ROCK2_HUMAN (475-1014): 3.87e-18: 92.4: 12.01
+	Hs
		338037 EGFR_HUMAN (105-387): 1.28e-52: 203: 38.87		MYH9_HUMAN (670-1018): 2.79e-13: 76.9: 12.82