HitPredict

Interactor 1: SLK (O54988)
STE20-like serine/threonine-protein kinase (STE20-like kinase) (mSLK) (EC 2.7.11.1) (Etk4) (STE20-related kinase SMAK) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2)
Gene: SLK

Interactor 2: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	27507650, 28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase, Pkinase~SAM_1
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1233 Mm			1 1730
+	Mm
		823533 CTRO_MOUSE (8-1228): 3.71e-145: 486: 15.99		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Mm
		975154 MARK3_MOUSE (12-766): 5.83e-141: 447: 14.61		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Mm
		949282 TNIK_MOUSE (29-323): 4.83e-55: 212: 40.92		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Hs
		862065 MARK2_HUMAN (1-766): 2.18e-148: 468: 15.64		DAPK1_HUMAN (17-450): 1.03e-87: 318: 15.97
+	Hs
		647851 MARK3_HUMAN (11-766): 1.02e-141: 449: 14.59		DAPK1_HUMAN (17-450): 1.03e-87: 318: 15.97
+	Hs
		862115 MARK1_HUMAN (6-766): 2.16e-133: 429: 15.05		DAPK1_HUMAN (17-450): 1.03e-87: 318: 15.97
+	Rn
		1144333 AKT3_RAT (1-337): 4.16e-112: 361: 26.51		CSKI1_RAT (55-1403): 1.26e-108: 382: 15.84
+	Mm
		1115981 MRCKB_MOUSE (485-1017): 5.27e-24: 112: 12.62		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Mm
		1115968 TAOK2_MOUSE (951-1227): 2.06e-20: 100: 14.00		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Hs
		1027432 STK3_HUMAN (15-307): 1.53e-112: 362: 41.50		Q9H4D1_HUMAN (1-279): 6.7e-66: 242: 18.21
+	Hs
		883501 STK3_HUMAN (15-307): 1.53e-112: 362: 41.50		RIPK4_HUMAN (1-279): 5.68e-65: 240: 18.21
+	Hs
		149481 CTRO_HUMAN (8-1228): 3.24e-152: 506: 15.04		PCLO_HUMAN (347-1361): 2.55e-17: 91.3: 10.90
+	Mm
		949353 TNIK_MOUSE (29-323): 4.83e-55: 212: 40.92		SHAN2_MOUSE (352-1727): 1.03e-90: 328: 35.55
+	Mm
		103596 TNIK_MOUSE (29-323): 4.83e-55: 212: 40.92		ANK3_MOUSE (41-592): 7.79e-85: 311: 15.58
+	Hs
		1330871 STK26_HUMAN (29-298): 4.29e-55: 199: 42.44		Q9H4D1_HUMAN (1-279): 6.7e-66: 242: 18.21
+	Mm
		1169651 TAOK2_MOUSE (951-1227): 2.06e-20: 100: 14.00		SHAN2_MOUSE (352-1727): 1.03e-90: 328: 35.55
+	Hs
		1071722 KS6A2_HUMAN (27-348): 2.74e-95: 323: 23.33		SHAN1_HUMAN (491-1637): 5.93e-12: 73.4: 14.37
+	Mm
		949287 TNIK_MOUSE (29-323): 4.83e-55: 212: 40.92		EHMT1_MOUSE (3-296): 2.87e-43: 175: 20.00
+	Mm
		88365 TNIK_MOUSE (29-323): 4.83e-55: 212: 40.92		SHAN1_MOUSE (367-1725): 5.86e-28: 126: 14.36
+	Mm
		949370 TNIK_MOUSE (29-323): 4.83e-55: 212: 40.92		ANK2_MOUSE (134-335): 6.85e-09: 63.5: 31.19