HitPredict

Interactor 1: NCK2 (O55033)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: DYN1 (P39053)
Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I)
Gene: Dnm1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	11557983
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~SH3_1, PH~SH3_9
Common GO terms	GO:0044877 - protein-containing complex binding GO:0045202 - synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Mm			1 867
+	Hs
		209034 NCK2_HUMAN (1-380): 1.15e-93: 287: 96.05		DYN1_HUMAN (1-845): 0: 1051: 99.65
+	Hs
		557664 NCK1_HUMAN (1-379): 1.12e-87: 271: 66.93		DYN1_HUMAN (1-845): 0: 1051: 99.65
+	Mm
		760469 ITSN1_MOUSE (5-306): 4.13e-20: 94.4: 14.48		DYN1_MOUSE (1-867): 0: 1087: 100.00
+	Rn
		599408 P85A_RAT (24-379): 1.69e-30: 124: 12.57		DYN1_RAT (1-845): 0: 1043: 98.34
+	Rn
		599413 ITSN1_RAT (5-306): 4.28e-27: 115: 15.26		DYN1_RAT (1-845): 0: 1043: 98.34
+	Hs
		983379 ITSN1_HUMAN (4-305): 7.9e-24: 105: 15.78		DYN1_HUMAN (1-845): 0: 1051: 99.65
+	Hs
		522926 SRC_HUMAN (7-120): 5.83e-16: 81.3: 18.10		DYN1_HUMAN (1-845): 0: 1051: 99.65
+	Ce
		760506 Q95PW9_CAEEL (1-379): 1.05e-70: 228: 38.38		DYN1_CAEEL (3-799): 0: 900: 64.25
+	Hs
		840840 ITSN2_HUMAN (5-300): 7.23e-34: 135: 18.60		DYN2_HUMAN (1-845): 0: 985: 77.93
+	Hs
		655274 P85A_HUMAN (24-379): 4.46e-31: 126: 12.57		DYN2_HUMAN (1-845): 0: 985: 77.93
+	Hs
		840702 ITSN1_HUMAN (4-305): 7.9e-24: 105: 15.78		DYN2_HUMAN (1-845): 0: 985: 77.93
+	Hs
		840686 GRAP_HUMAN (5-169): 7.33e-25: 102: 15.74		DYN2_HUMAN (1-845): 0: 985: 77.93
+	Hs
		442794 HCK_HUMAN (2-205): 1.34e-22: 101: 19.42		DYN2_HUMAN (1-845): 0: 985: 77.93
+	Hs
		412090 FYN_HUMAN (7-205): 4.93e-22: 99.5: 12.68		DYN2_HUMAN (1-845): 0: 985: 77.93
+	Hs
		412411 FYN_HUMAN (7-205): 4.93e-22: 99.5: 12.68		DYN3_HUMAN (1-839): 0: 981: 78.64
+	Mm
		760488 ITSN1_MOUSE (5-306): 4.13e-20: 94.4: 14.48		DYN2_MOUSE (1-845): 0: 986: 78.28
+	Hs
		522862 SRC_HUMAN (7-120): 5.83e-16: 81.3: 18.10		DYN2_HUMAN (1-845): 0: 985: 77.93
+	Dm
		649302 GRAP_DROME (204-368): 5.66e-18: 83.6: 32.53		DYN_DROME (6-845): 0: 920: 65.93
+	Ce
		220206 SRC2_CAEEL (1-156): 2.83e-19: 91: 18.41		DYN1_CAEEL (3-799): 0: 900: 64.25
+	Ce
		666206 SEM5_CAEEL (204-364): 1.26e-16: 80.1: 31.29		DYN1_CAEEL (3-799): 0: 900: 64.25