HitPredict

Interactor 1: NCK2 (O55033)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: DLG4 (Q62108)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36604605
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH3_1, Guanylate_kin~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0014069 - postsynaptic density GO:0044877 - protein-containing complex binding GO:0045202 - synapse GO:0097110 - scaffold protein binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 380 Mm			1 724
+	Hs
		412128 FYN_HUMAN (7-205): 4.93e-22: 99.5: 12.68		DLG4_HUMAN (1-724): 0: 671: 99.59
+	Mm
		403445 SRC_MOUSE (7-120): 5.82e-16: 81.3: 18.10		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Mm
		1141133 GRB2_MOUSE (1-60): 1.6e-16: 79.5: 29.51		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Hs
		924466 GRB2_HUMAN (3-60): 3.75e-16: 78.7: 31.03		DLG4_HUMAN (1-724): 0: 671: 99.59
+	Hs
		655344 P85A_HUMAN (24-379): 4.46e-31: 126: 12.57		DLG1_HUMAN (28-724): 0: 576: 72.79
+	Hs
		129286 P85B_HUMAN (2-379): 2.19e-30: 124: 12.53		DLG1_HUMAN (28-724): 0: 576: 72.79
+	Hs
		557746 NCK1_HUMAN (1-379): 1.12e-87: 271: 66.93		DLG5_HUMAN (40-245): 4.01e-17: 88.6: 31.55
+	Hs
		159139 HCK_HUMAN (2-205): 1.34e-22: 101: 19.42		CSKP_HUMAN (6-381): 1.53e-20: 99: 14.43
+	Hs
		522978 SRC_HUMAN (7-120): 5.83e-16: 81.3: 18.10		MPP2_HUMAN (2-189): 1.25e-16: 85.9: 15.71
+	Rn
		73322 SRC_RAT (7-123): 3.04e-17: 85.3: 17.65		PALS1_RAT (22-196): 9.47e-14: 76.7: 14.21