HitPredict

Interactor 1: NCK2 (O55033)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: ABI1 (Q8CBW3)
Abl interactor 1 (Abelson interactor 1) (Abi-1) (Ablphilin-1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Spectrin SH3 domain-binding protein 1) (e3B1)
Gene: ABI1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	11557983
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0014069 - postsynaptic density GO:0035591 - signaling adaptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Mm			1 481
+	Hs
		209108 NCK2_HUMAN (1-380): 1.15e-93: 287: 96.05		ABI1_HUMAN (1-481): 1.34e-109: 336: 93.11
+	Hs
		557737 NCK1_HUMAN (1-379): 1.12e-87: 271: 66.93		ABI1_HUMAN (1-481): 1.34e-109: 336: 93.11
+	Hs
		209180 NCK2_HUMAN (1-380): 1.15e-93: 287: 96.05		ABI2_HUMAN (1-481): 2.09e-72: 239: 61.79
+	Hs
		557806 NCK1_HUMAN (1-379): 1.12e-87: 271: 66.93		ABI2_HUMAN (1-481): 2.09e-72: 239: 61.79
+	Mm
		643107 P85A_MOUSE (24-379): 1.32e-31: 128: 12.57		ABI1_MOUSE (1-481): 7.25e-118: 356: 100.00
+	Hs
		655418 P85A_HUMAN (24-379): 4.46e-31: 126: 12.57		ABI1_HUMAN (1-481): 1.34e-109: 336: 93.11
+	Hs
		129316 P85B_HUMAN (2-379): 2.19e-30: 124: 12.53		ABI1_HUMAN (1-481): 1.34e-109: 336: 93.11
+	Hs
		3136 A0A0S2Z4D7_HUMAN (1-138): 3.25e-60: 193: 67.39		ABI2_HUMAN (1-481): 2.09e-72: 239: 61.79
+	Hs
		209187 NCK2_HUMAN (1-380): 1.15e-93: 287: 96.05		ASAP1_HUMAN (59-478): 1.09e-35: 143: 16.91
+	Hs
		557823 NCK1_HUMAN (1-379): 1.12e-87: 271: 66.93		ASAP1_HUMAN (59-478): 1.09e-35: 143: 16.91
+	Rn
		71363 B2RZ33_RAT (1-379): 8.26e-88: 272: 67.45		SRC8_RAT (261-475): 5.7e-33: 133: 19.28
+	Hs
		203208 NCK1_HUMAN (1-379): 1.12e-87: 271: 66.93		SYNJ1_HUMAN (38-402): 7.12e-31: 129: 15.16
+	Hs
		209184 NCK2_HUMAN (1-380): 1.15e-93: 287: 96.05		ABI3_HUMAN (276-475): 6.49e-15: 78: 24.04
+	Hs
		827763 ITSN2_HUMAN (5-300): 7.23e-34: 135: 18.60		AMPH_HUMAN (3-476): 6.59e-41: 157: 12.28
+	Hs
		655502 P85A_HUMAN (24-379): 4.46e-31: 126: 12.57		ASAP1_HUMAN (59-478): 1.09e-35: 143: 16.91
+	Hs
		279897 ITSN2_HUMAN (5-300): 7.23e-34: 135: 18.60		TRIO_HUMAN (189-481): 6.17e-31: 129: 15.41
+	Hs
		203228 ITSN1_HUMAN (4-305): 7.9e-24: 105: 15.78		SYNJ1_HUMAN (38-402): 7.12e-31: 129: 15.16
+	Hs
		1349275 ITSN2_HUMAN (5-300): 7.23e-34: 135: 18.60		ITSN2_HUMAN (340-480): 6.29e-13: 73.7: 18.88
+	Hs
		1078919 ITSN2_HUMAN (5-300): 7.23e-34: 135: 18.60		ITSN1_HUMAN (294-480): 4.54e-11: 67.6: 12.82
+	Hs
		655386 P85A_HUMAN (24-379): 4.46e-31: 126: 12.57		ITSN1_HUMAN (294-480): 4.54e-11: 67.6: 12.82