HitPredict

Interactor 1: CLR6 (O59702)
Histone deacetylase clr6 (EC 3.5.1.98) (Cryptic loci regulator 6)
Gene: CLR6

Interactor 2: YAC5 (Q09819)
Uncharacterized protein C16C9.05
Gene: SPAC16C9.05

Species: Schizosaccharomyces pombe 972h-

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	17450151
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0032221 - Rpd3S complex GO:0045815 - transcription initiation-coupled chromatin remodeling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 405 Sp			1 404
+	Hs
		782341 HDAC1_HUMAN (2-386): 0: 596: 63.64		KDM5C_HUMAN (2-288): 6.92e-40: 154: 13.71
+	Hs
		1038791 HDAC1_HUMAN (2-386): 0: 596: 63.64		BAZ2A_HUMAN (56-331): 3.63e-35: 140: 13.62
+	Hs
		1038782 HDAC1_HUMAN (2-386): 0: 596: 63.64		KDM5B_HUMAN (17-288): 1.86e-34: 137: 13.38
+	Mm
		140293 HDAC1_MOUSE (2-386): 0: 597: 63.90		KDM5B_MOUSE (17-288): 1.65e-32: 132: 14.05
+	Mm
		56897 HDAC1_MOUSE (2-386): 0: 597: 63.90		CHD5_MOUSE (66-271): 4.41e-32: 130: 13.48
+	Mm
		140286 HDAC1_MOUSE (2-386): 0: 597: 63.90		CHD4_MOUSE (66-271): 4.1e-31: 127: 13.85
+	Hs
		1038563 HDAC1_HUMAN (2-386): 0: 596: 63.64		CHD5_HUMAN (1-298): 4.19e-30: 125: 15.00
+	Hs
		666529 HDAC1_HUMAN (2-386): 0: 596: 63.64		KDM5A_HUMAN (20-288): 2.02e-30: 125: 13.51
+	Dm
		332806 HDAC1_DROME (3-405): 0: 585: 59.90		CHDM_DROME (17-303): 9.55e-31: 127: 11.47
+	Hs
		170356 HDAC1_HUMAN (2-386): 0: 596: 63.64		TIF1A_HUMAN (13-173): 4.88e-27: 115: 25.61
+	Hs
		1038620 HDAC1_HUMAN (2-386): 0: 596: 63.64		PF21B_HUMAN (10-172): 1.2e-24: 107: 18.39
+	Hs
		1038382 HDAC1_HUMAN (2-386): 0: 596: 63.64		CHD4_HUMAN (14-298): 6.77e-23: 103: 11.36
+	Hs
		1038817 HDAC1_HUMAN (2-386): 0: 596: 63.64		ZMYD8_HUMAN (27-164): 5.86e-22: 100: 30.94
+	Dm
		1276536 HDAC1_DROME (3-405): 0: 585: 59.90		Q9VDK5_DROME (42-163): 7.1e-25: 109: 21.64
+	Dm
		68996 HDAC1_DROME (3-405): 0: 585: 59.90		A8WHL4_DROME (42-163): 7.92e-25: 109: 21.64
+	Hs
		217477 HDAC1_HUMAN (2-386): 0: 596: 63.64		AIRE_HUMAN (115-163): 8.55e-19: 90.2: 51.02
+	Hs
		1018465 HDAC1_HUMAN (2-386): 0: 596: 63.64		CHD3_HUMAN (10-298): 3.73e-16: 82.8: 11.77
+	Hs
		1038610 HDAC1_HUMAN (2-386): 0: 596: 63.64		PF21A_HUMAN (65-164): 2.68e-13: 73.6: 27.00
+	Hs
		1038642 HDAC1_HUMAN (2-386): 0: 596: 63.64		PHF12_HUMAN (6-205): 6.74e-13: 72.7: 18.27
+	Mm
		140269 HDAC1_MOUSE (2-386): 0: 597: 63.90		PHF12_MOUSE (6-205): 1.41e-11: 68.5: 18.27