HitPredict

Interactor 1: ASH2 (O60070)
Set1 complex component ash2 (Set1C component ash2) (COMPASS component ash2) (Complex proteins associated with set1 protein ash2) (Lid2 complex component ash2) (Lid2C component ash2)
Gene: ASH2

Interactor 2: SET1 (Q9Y7R4)
Histone-lysine N-methyltransferase, H3 lysine-4 specific (EC 2.1.1.354) (COMPASS component set1) (Lysine N-methyltransferase 2) (SET domain-containing protein 1) (Set1 complex component set1) (Set1C component set1) (Spset1)
Gene: SET1

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	14617822
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SET~SPRY
Common GO terms	GO:0000785 - chromatin GO:0045815 - transcription initiation-coupled chromatin remodeling GO:0048188 - Set1C/COMPASS complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 652 Sp			1 920
+	Hs
		1080434 ASH2L_HUMAN (31-637): 8.77e-150: 449: 23.77		EZH2_HUMAN (370-903): 3.92e-106: 347: 17.52
+	Hs
		975339 ASH2L_HUMAN (31-637): 8.77e-150: 449: 23.77		KMT2A_HUMAN (385-920): 4.59e-79: 284: 24.36
+	Dm
		1129071 ASH2_DROME (31-625): 9.6e-146: 436: 25.20		SET1_DROME (360-920): 1.54e-77: 279: 24.51
+	Hs
		1354087 ASH2L_HUMAN (31-637): 8.77e-150: 449: 23.77		SET1B_HUMAN (571-920): 2.5e-73: 266: 37.90
+	Hs
		165730 ASH2L_HUMAN (31-637): 8.77e-150: 449: 23.77		SET1A_HUMAN (625-920): 2.98e-68: 250: 44.22
+	Dm
		594805 ASH2_DROME (31-625): 9.6e-146: 436: 25.20		TRX_DROME (526-920): 4.61e-69: 254: 25.92
+	Hs
		1354085 ASH2L_HUMAN (31-637): 8.77e-150: 449: 23.77		KMT2B_HUMAN (695-920): 5.97e-61: 228: 41.92
+	Hs
		198028 PHF1_HUMAN (2-367): 1.81e-90: 293: 17.30		EZH1_HUMAN (366-903): 7.13e-120: 383: 17.73
+	Mm
		936644 MTF2_MOUSE (2-381): 9.27e-86: 282: 17.88		EZH1_MOUSE (366-903): 3.42e-121: 387: 18.10
+	Hs
		1271119 MTF2_HUMAN (2-379): 8.9e-87: 284: 18.44		EZH1_HUMAN (366-903): 7.13e-120: 383: 17.73
+	Mm
		1207211 ASH2L_MOUSE (31-637): 2.78e-150: 450: 23.61		KMT2C_MOUSE (694-920): 2.07e-55: 211: 37.83
+	Hs
		1243848 ASH2L_HUMAN (31-637): 8.77e-150: 449: 23.77		KMT2C_HUMAN (694-920): 2.88e-55: 211: 37.56
+	Dm
		1215700 ASH2_DROME (31-625): 9.6e-146: 436: 25.20		TRR_DROME (655-920): 3.87e-59: 223: 30.60
+	Hs
		152695 ASH2L_HUMAN (31-637): 8.77e-150: 449: 23.77		KMT2D_HUMAN (703-920): 4.84e-52: 201: 38.46
+	Hs
		197991 PHF1_HUMAN (2-367): 1.81e-90: 293: 17.30		EZH2_HUMAN (370-903): 3.92e-106: 347: 17.52
+	Mm
		1142302 PHF1_MOUSE (2-367): 1.94e-88: 288: 16.76		EZH2_MOUSE (373-903): 3.15e-106: 347: 17.10
+	Hs
		1080516 MTF2_HUMAN (2-379): 8.9e-87: 284: 18.44		EZH2_HUMAN (370-903): 3.92e-106: 347: 17.52
+	Mm
		970680 MTF2_MOUSE (2-381): 9.27e-86: 282: 17.88		EZH2_MOUSE (373-903): 3.15e-106: 347: 17.10
+	Hs
		203819 MTF2_HUMAN (2-379): 8.9e-87: 284: 18.44		SUV91_HUMAN (620-919): 1.38e-76: 257: 18.80
+	Hs
		1331981 MTF2_HUMAN (2-379): 8.9e-87: 284: 18.44		SUV92_HUMAN (620-920): 4.49e-74: 251: 19.36