HitPredict

Interactor 1: MYPT2 (O60237)
Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2)
Gene: PPP1R12B

Interactor 2: ASB1 (Q9Y576)
Ankyrin repeat and SOCS box protein 1 (ASB-1)
Gene: ASB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank~Ank_2, Ank_2~Ank_2, Ank_2~SOCS_box
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 982 Hs			1 335
+	Hs
		225123 MYPT2_HUMAN (1-982): 7.66e-163: 505: 100.00		ANK1_HUMAN (3-188): 3.95e-52: 186: 24.19
+	Hs
		225117 MYPT2_HUMAN (1-982): 7.66e-163: 505: 100.00		TNKS1_HUMAN (4-244): 2.61e-50: 181: 20.39
+	Hs
		225134 MYPT2_HUMAN (1-982): 7.66e-163: 505: 100.00		ANK2_HUMAN (3-163): 6.4e-46: 169: 24.85
+	Hs
		225160 MYPT2_HUMAN (1-982): 7.66e-163: 505: 100.00		TNKS2_HUMAN (115-325): 3.4e-27: 114: 15.39
+	Hs
		225115 MYPT2_HUMAN (1-982): 7.66e-163: 505: 100.00		ANR17_HUMAN (3-59): 2.58e-12: 69.9: 19.30
+	Hs
		225146 MYPT2_HUMAN (1-982): 7.66e-163: 505: 100.00		ANKH1_HUMAN (3-59): 7.17e-11: 65.7: 17.54
+	Hs
		225167 MYPT2_HUMAN (1-982): 7.66e-163: 505: 100.00		ASB3_HUMAN (150-291): 1.35e-09: 61.2: 19.72
+	Hs
		225136 MYPT2_HUMAN (1-982): 7.66e-163: 505: 100.00		ANK3_HUMAN (3-56): 7.49e-09: 59.5: 18.52
+	Mm
		1193396 MIB1_MOUSE (2-397): 1.06e-73: 265: 18.99		DAPK1_MOUSE (3-163): 4.52e-39: 149: 19.26
+	Hs
		862070 MIB1_HUMAN (2-397): 4.04e-73: 263: 18.75		DAPK1_HUMAN (3-163): 5.2e-40: 151: 18.63
+	Hs
		883487 RIPK4_HUMAN (21-365): 7.55e-66: 239: 21.07		ANK2_HUMAN (3-163): 6.4e-46: 169: 24.85
+	Hs
		965154 Q9H4D1_HUMAN (21-365): 2.96e-65: 237: 21.07		ANK2_HUMAN (3-163): 6.4e-46: 169: 24.85
+	Hs
		862028 ANK2_HUMAN (38-320): 2.2e-60: 228: 21.58		DAPK1_HUMAN (3-163): 5.2e-40: 151: 18.63
+	Mm
		970499 ANS1B_MOUSE (62-880): 1.66e-74: 270: 16.39		ANK1_MOUSE (4-97): 2.24e-17: 85.3: 23.40
+	Mm
		1206648 ANS1B_MOUSE (62-880): 1.66e-74: 270: 16.39		Q8C103_MOUSE (3-59): 7.97e-10: 62.2: 17.54
+	Hs
		883691 RIPK4_HUMAN (21-365): 7.55e-66: 239: 21.07		ASB3_HUMAN (150-291): 1.35e-09: 61.2: 19.72
+	Hs
		883496 RIPK4_HUMAN (21-365): 7.55e-66: 239: 21.07		ANK3_HUMAN (3-56): 7.49e-09: 59.5: 18.52
+	Hs
		1330905 Q9H4D1_HUMAN (21-365): 2.96e-65: 237: 21.07		ASB3_HUMAN (150-291): 1.35e-09: 61.2: 19.72
+	Hs
		257652 ANR17_HUMAN (2-882): 9.92e-62: 232: 12.57		ANKH1_HUMAN (3-59): 7.17e-11: 65.7: 17.54
+	Hs
		1021462 Q9H4D1_HUMAN (21-365): 2.96e-65: 237: 21.07		ANK3_HUMAN (3-56): 7.49e-09: 59.5: 18.52