HitPredict

Interactor 1: MED14 (O60244)
Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150)
Gene: MED14

Interactor 2: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1454 Hs			1 1130
+	Hs
		225333 MED14_HUMAN (1-1454): 0: 1560: 100.00		FYN_HUMAN (18-510): 0: 543: 38.64
+	Hs
		337335 MUC1_HUMAN (958-1293): 3.26e-12: 73.7: 15.23		ABL1_HUMAN (1-1130): 0: 984: 100.00
+	Hs
		297808 K0754_HUMAN (1071-1454): 6.75e-24: 112: 11.54		LYN_HUMAN (9-508): 9.12e-173: 519: 36.15
+	Hs
		411844 TB182_HUMAN (945-1135): 6.75e-20: 99.2: 18.33		LCK_HUMAN (9-508): 3.02e-177: 531: 38.49
+	Hs
		523092 CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70		SRC_HUMAN (13-510): 0: 547: 38.58
+	Hs
		522749 MUC1_HUMAN (958-1293): 3.26e-12: 73.7: 15.23		SRC_HUMAN (13-510): 0: 547: 38.58
+	Hs
		433989 TB182_HUMAN (945-1135): 6.75e-20: 99.2: 18.33		LYN_HUMAN (9-508): 9.12e-173: 519: 36.15
+	Hs
		411582 MUC1_HUMAN (958-1293): 3.26e-12: 73.7: 15.23		LCK_HUMAN (9-508): 3.02e-177: 531: 38.49
+	Hs
		442866 CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70		HCK_HUMAN (9-508): 5.18e-175: 526: 38.79
+	Hs
		433930 CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70		LYN_HUMAN (9-508): 9.12e-173: 519: 36.15
+	Hs
		433560 MUC1_HUMAN (958-1293): 3.26e-12: 73.7: 15.23		LYN_HUMAN (9-508): 9.12e-173: 519: 36.15
+	Mm
		101424 F8VPR5_MOUSE (836-1217): 4.53e-09: 63.8: 7.75		LYN_MOUSE (9-508): 4.68e-172: 517: 35.77
+	Hs
		782795 TENS2_HUMAN (905-1243): 1.16e-17: 91.8: 14.14		CSK_HUMAN (61-500): 1.81e-155: 472: 37.72
+	Mm
		101430 F8VPR5_MOUSE (836-1217): 4.53e-09: 63.8: 7.75		CSK_MOUSE (61-500): 2.58e-155: 472: 37.95