HitPredict

Interactor 1: MED14 (O60244)
Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150)
Gene: MED14

Interactor 2: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	37045861
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Med14~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0035019 - somatic stem cell population maintenance GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1454 Hs			1 648
+	Hs
		225333 MED14_HUMAN (1-1454): 0: 1560: 100.00		FYN_HUMAN (337-607): 2.33e-103: 326: 34.55
+	Hs
		375022 RERE_HUMAN (945-1199): 7.88e-10: 66: 14.60		RAF1_HUMAN (1-648): 0: 652: 100.00
+	Hs
		374088 IF4G1_HUMAN (840-1368): 3.72e-09: 63.8: 10.72		RAF1_HUMAN (1-648): 0: 652: 100.00
+	Hs
		1217989 KI13B_HUMAN (961-1173): 3.7e-21: 103: 16.24		KSR1_HUMAN (138-648): 6.15e-108: 348: 24.61
+	Hs
		523092 CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70		SRC_HUMAN (331-607): 3.01e-106: 333: 33.45
+	Hs
		522749 MUC1_HUMAN (958-1293): 3.26e-12: 73.7: 15.23		SRC_HUMAN (331-607): 3.01e-106: 333: 33.45