HitPredict

Interactor 1: MED14 (O60244)
Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150)
Gene: MED14

Interactor 2: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	23746844
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1454 Hs			1 826
+	Hs
		225413 MED14_HUMAN (1-1454): 0: 1560: 100.00		EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24
+	Hs
		1085623 CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70		HIF1A_HUMAN (1-826): 0: 741: 100.00
+	Hs
		554312 MUC1_HUMAN (958-1293): 3.26e-12: 73.7: 15.23		HIF1A_HUMAN (1-826): 0: 741: 100.00
+	Rn
		193481 CBP_RAT (836-1217): 1.43e-09: 65.3: 8.01		HIF1A_RAT (1-826): 0: 714: 89.40
+	Hs
		1270775 CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70		EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24
+	Hs
		625014 RPB1_HUMAN (1059-1159): 8.88e-09: 62.5: 23.30		EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24
+	Hs
		1075384 CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70		NCOA2_HUMAN (1-747): 3.97e-109: 367: 15.62
+	Hs
		1270774 CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70		NPAS2_HUMAN (5-749): 1.34e-113: 367: 18.32
+	Hs
		126156 CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70		BMAL1_HUMAN (7-505): 9.03e-114: 361: 20.88
+	Mm
		799605 CBP_MOUSE (836-1217): 4.2e-09: 63.8: 7.75		BMAL1_MOUSE (7-505): 2.8e-116: 368: 20.92
+	Hs
		181549 CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70		CLOCK_HUMAN (2-696): 1.68e-102: 338: 18.24
+	Hs
		1270854 CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70		NCOA3_HUMAN (1-746): 4.42e-98: 335: 15.31
+	Mm
		101411 F8VPR5_MOUSE (836-1217): 4.53e-09: 63.8: 7.75		CLOCK_MOUSE (2-704): 2.25e-102: 338: 17.88
+	Mm
		799600 CBP_MOUSE (836-1217): 4.2e-09: 63.8: 7.75		BMAL2_MOUSE (13-508): 3.25e-100: 324: 20.86