HitPredict

Interactor 1: MED14 (O60244)
Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150)
Gene: MED14

Interactor 2: MD13L (Q71F56)
Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like)
Gene: MED13L

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	24981860, 35271311, 36950384
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003712 - transcription coregulator activity GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0016592 - mediator complex
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1454 Hs			1 2210
+	Hs
		225433 MED14_HUMAN (1-1454): 0: 1560: 100.00		MED13_HUMAN (4-2210): 0: 3181: 51.34
+	Hs
		624943 RPB1_HUMAN (1059-1159): 8.88e-09: 62.5: 23.30		MD13L_HUMAN (1-2210): 0: 3763: 100.00
+	Hs
		625086 RPB1_HUMAN (1059-1159): 8.88e-09: 62.5: 23.30		MED13_HUMAN (4-2210): 0: 3181: 51.34
+	Dm
		1182316 MED14_DROME (23-1453): 0: 1157: 36.49		MED13_DROME (943-1152): 8.63e-10: 66.7: 23.77