HitPredict

Interactor 1: MED14 (O60244)
Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150)
Gene: MED14

Interactor 2: HECW2 (Q9P2P5)
E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2)
Gene: HECW2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	24163370
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1454 Hs			1 1572
+	Hs
		1350517 CABIN_HUMAN (969-1229): 1.65e-25: 117: 15.39		HECW2_HUMAN (1-1572): 0: 1176: 100.00
+	Hs
		1295414 CHAP1_HUMAN (919-1278): 9.7e-18: 91.5: 13.94		HECW2_HUMAN (1-1572): 0: 1176: 100.00
+	Hs
		1170093 SRCAP_HUMAN (853-1422): 3.36e-09: 64.2: 9.60		HECW2_HUMAN (1-1572): 0: 1176: 100.00
+	Hs
		1144558 TENS2_HUMAN (905-1243): 1.16e-17: 91.8: 14.14		HUWE1_HUMAN (1007-1571): 2.14e-157: 535: 31.55
+	Hs
		1192147 CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70		HUWE1_HUMAN (1007-1571): 2.14e-157: 535: 31.55
+	Hs
		625052 RPB1_HUMAN (1059-1159): 8.88e-09: 62.5: 23.30		SMUF1_HUMAN (177-586): 4.19e-31: 134: 13.74
+	Hs
		123777 SPT5H_HUMAN (1062-1272): 9.25e-11: 68.8: 14.41		WWP2_HUMAN (523-857): 7e-16: 85.6: 13.18
+	Hs
		554367 MUC1_HUMAN (958-1293): 3.26e-12: 73.7: 15.23		WWP1_HUMAN (614-936): 3.01e-14: 80.2: 16.36
+	Hs
		125061 SC24D_HUMAN (986-1164): 5.57e-10: 66.4: 18.79		WWP2_HUMAN (523-857): 7e-16: 85.6: 13.18
+	Hs
		125395 IF4G1_HUMAN (840-1368): 3.72e-09: 63.8: 10.72		WWP2_HUMAN (523-857): 7e-16: 85.6: 13.18
+	Hs
		125161 RPB1_HUMAN (1059-1159): 8.88e-09: 62.5: 23.30		WWP2_HUMAN (523-857): 7e-16: 85.6: 13.18
+	Mm
		444988 RPB1_MOUSE (1059-1159): 6.56e-09: 62.9: 23.30		WWP2_MOUSE (490-857): 8.37e-16: 85.2: 12.33
+	Hs
		625031 RPB1_HUMAN (1059-1159): 8.88e-09: 62.5: 23.30		WWP1_HUMAN (614-936): 3.01e-14: 80.2: 16.36
+	Hs
		624804 RPB1_HUMAN (1059-1159): 8.88e-09: 62.5: 23.30		NEDD4_HUMAN (262-640): 1.79e-13: 77.9: 10.41
+	Hs
		624998 RPB1_HUMAN (1059-1159): 8.88e-09: 62.5: 23.30		ITCH_HUMAN (468-850): 1.52e-10: 68.3: 12.37