HitPredict

Interactor 1: MED14 (O60244)
Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150)
Gene: MED14

Interactor 2: TRRAP (Q9Y4A5)
Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog)
Gene: TRRAP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	18418385
Identification Methods	biochemical
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003712 - transcription coregulator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1454 Hs			1 3859
+	Hs
		980038 IF4G1_HUMAN (840-1368): 3.72e-09: 63.8: 10.72		TRRAP_HUMAN (1-3859): 0: 4445: 100.00
+	Sc
		581362 MED14_YEAST (2-463): 8.6e-138: 453: 18.45		TRA1_YEAST (16-3859): 0: 3030: 26.48
+	Hs
		554305 MUC1_HUMAN (958-1293): 3.26e-12: 73.7: 15.23		ATM_HUMAN (2081-3858): 0: 1072: 12.80
+	Hs
		624886 RPB1_HUMAN (1059-1159): 8.88e-09: 62.5: 23.30		ATM_HUMAN (2081-3858): 0: 1072: 12.80