HitPredict

Interactor 1: SOX15 (O60248)
Transcription factor SOX-15 (Protein SOX-12) (Protein SOX-20) (SRY-box transcription factor 15)
Gene: SOX15

Interactor 2: TFAM (Q00059)
Transcription factor A, mitochondrial (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6) (TCF-6) (Transcription factor 6-like 2)
Gene: TFAM

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	35140242
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HMG_box~HMG_box, HMG_box~HMG_box_2
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 246
+	Hs
		881795 SOX10_HUMAN (43-142): 2.82e-37: 137: 51.49		TFAM_HUMAN (1-246): 1.85e-62: 197: 100.00
+	Hs
		727727 SOX5_HUMAN (21-132): 3.84e-35: 133: 41.07		TFAM_HUMAN (1-246): 1.85e-62: 197: 100.00
+	Hs
		225791 SOX15_HUMAN (1-233): 8.57e-47: 156: 100.00		HM20A_HUMAN (45-146): 3.64e-24: 100: 19.61
+	Hs
		133759 SOX1_HUMAN (14-122): 2.38e-39: 141: 58.26		SOX5_HUMAN (49-150): 1.14e-23: 101: 12.75
+	Hs
		727705 SOX5_HUMAN (21-132): 3.84e-35: 133: 41.07		SOX6_HUMAN (49-160): 2.17e-25: 106: 12.82
+	Mm
		727702 SOX5_MOUSE (19-132): 4.9e-35: 133: 40.35		SOX6_MOUSE (49-160): 4.99e-25: 105: 12.82
+	Hs
		881829 SOX10_HUMAN (43-142): 2.82e-37: 137: 51.49		HM20A_HUMAN (45-146): 3.64e-24: 100: 19.61
+	Hs
		727704 SOX5_HUMAN (21-132): 3.84e-35: 133: 41.07		SOX5_HUMAN (49-150): 1.14e-23: 101: 12.75
+	Hs
		727941 SOX13_HUMAN (15-132): 1.93e-33: 128: 41.46		SOX6_HUMAN (49-160): 2.17e-25: 106: 12.82
+	Hs
		727808 SOX5_HUMAN (21-132): 3.84e-35: 133: 41.07		HM20A_HUMAN (45-146): 3.64e-24: 100: 19.61
+	Hs
		727836 SOX2_HUMAN (11-229): 9.17e-35: 127: 38.46		SOX6_HUMAN (49-160): 2.17e-25: 106: 12.82
+	Hs
		727795 SOX5_HUMAN (21-132): 3.84e-35: 133: 41.07		SOX7_HUMAN (121-230): 1.71e-22: 96.4: 14.91
+	Dm
		114544 M9PCZ7_DROME (18-225): 1.24e-33: 129: 40.38		M9PFG6_DROME (123-232): 2.76e-23: 99.1: 14.91
+	Hs
		727709 SOX2_HUMAN (11-229): 9.17e-35: 127: 38.46		SOX5_HUMAN (49-150): 1.14e-23: 101: 12.75
+	Hs
		313690 SOX2_HUMAN (11-229): 9.17e-35: 127: 38.46		SOX14_HUMAN (150-235): 8.56e-24: 97.5: 22.22
+	Hs
		727827 SOX5_HUMAN (21-132): 3.84e-35: 133: 41.07		SOX13_HUMAN (142-226): 5.28e-17: 81.7: 14.61
+	Hs
		1357429 SOX13_HUMAN (15-132): 1.93e-33: 128: 41.46		SOX13_HUMAN (142-226): 5.28e-17: 81.7: 14.61
+	Dm
		114457 M9PCG2_DROME (3-217): 7.77e-36: 135: 35.65		PANG1_DROME (122-221): 9.89e-12: 66.3: 12.50
+	Hs
		567658 SOX2_HUMAN (11-229): 9.17e-35: 127: 38.46		UBF1_HUMAN (51-214): 4.22e-11: 64.4: 20.46