HitPredict

Interactor 1: SOX15 (O60248)
Transcription factor SOX-15 (Protein SOX-12) (Protein SOX-20) (SRY-box transcription factor 15)
Gene: SOX15

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005667 - transcription regulator complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 197
+	Hs
		225730 SOX15_HUMAN (1-233): 8.57e-47: 156: 100.00		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		225731 SOX15_HUMAN (1-233): 8.57e-47: 156: 100.00		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		881797 SOX10_HUMAN (43-142): 2.82e-37: 137: 51.49		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		818792 SOX9_HUMAN (38-179): 3.1e-36: 135: 40.14		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		727732 SOX5_HUMAN (21-132): 3.84e-35: 133: 41.07		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		817954 SOX2_HUMAN (11-229): 9.17e-35: 127: 38.46		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		727850 SOX6_HUMAN (24-222): 2.2e-30: 120: 25.63		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		980649 SOX17_HUMAN (46-229): 8.91e-31: 118: 36.02		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		980642 SOX7_HUMAN (9-232): 2.31e-29: 114: 27.89		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		817955 SOX2_HUMAN (11-229): 9.17e-35: 127: 38.46		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		727851 SOX6_HUMAN (24-222): 2.2e-30: 120: 25.63		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		980859 SOX7_HUMAN (9-232): 2.31e-29: 114: 27.89		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		727734 SOX5_HUMAN (21-132): 3.84e-35: 133: 41.07		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		817967 SOX2_HUMAN (11-229): 9.17e-35: 127: 38.46		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		567682 UBF1_HUMAN (27-193): 3.98e-15: 75.8: 10.71		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		993604 SOX17_HUMAN (46-229): 8.91e-31: 118: 36.02		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Dm
		558375 DICH_DROME (45-207): 5.58e-28: 111: 44.79		GROU_DROME (2-163): 3.54e-59: 198: 54.44