HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: U520 (O75643)
U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD)
Gene: SNRNP200

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	32929329, 35509820, 35256949, 24244333
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 2136
+	Hs
		272197 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		U520_HUMAN (1-2136): 0: 1844: 100.00
+	At
		1092410 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		DEXHC_ARATH (2-2130): 0: 1646: 56.50
+	At
		221257 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		DEXHD_ARATH (2-2130): 0: 1626: 55.06
+	Hs
		476041 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ASCC3_HUMAN (56-2134): 0: 1449: 38.34
+	At
		98670 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		F4K203_ARATH (27-2123): 0: 1423: 38.57
+	Hs
		226462 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DDX5_HUMAN (1241-1718): 1.86e-108: 362: 12.47
+	Hs
		227955 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DDX42_HUMAN (231-900): 2.59e-103: 357: 13.42
+	Hs
		228251 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DDX17_HUMAN (405-901): 6.31e-105: 356: 13.72
+	Hs
		226754 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MTREX_HUMAN (1287-2037): 2.62e-101: 354: 18.12
+	Hs
		227539 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SKI2_HUMAN (1292-1738): 8.82e-97: 344: 24.21
+	Hs
		228549 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DDX23_HUMAN (1241-1748): 1.71e-87: 307: 14.36
+	Hs
		224731 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DHX16_HUMAN (1094-2008): 1.27e-67: 252: 11.11
+	Hs
		227453 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DHX8_HUMAN (1313-1903): 1.71e-65: 247: 11.81
+	Hs
		228233 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PRP16_HUMAN (1317-1920): 4.33e-65: 246: 11.76
+	Hs
		312636 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		DDX17_HUMAN (405-901): 6.31e-105: 356: 13.72
+	Hs
		476139 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DDX17_HUMAN (405-901): 6.31e-105: 356: 13.72
+	At
		1013123 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		DNJ21_ARATH (1819-2128): 1.93e-74: 265: 26.21
+	Hs
		224752 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DHX16_HUMAN (1094-2008): 1.27e-67: 252: 11.11
+	Hs
		475760 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DHX8_HUMAN (1313-1903): 1.71e-65: 247: 11.81
+	Pf
		1181541 Q7KQK2_PLAF7 (1-76): 8.17e-31: 124: 28.95		Q8I416_PLAF7 (1303-1710): 2.05e-48: 193: 14.56