HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: MTA2 (O94776)
Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex)
Gene: MTA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	35509820, 35987950, 35256949
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0042826 - histone deacetylase binding GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 668
+	Hs
		227357 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MTA1_HUMAN (1-668): 0: 704: 56.24
+	Hs
		228532 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MTA3_HUMAN (1-570): 0: 660: 64.24
+	Hs
		228409 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TREF1_HUMAN (136-487): 1.3e-57: 213: 17.12
+	Hs
		476549 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RCOR1_HUMAN (145-597): 1.42e-65: 225: 15.27