HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: RHBT1 (O94844)
Rho-related BTB domain-containing protein 1
Gene: RHOBTB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0019901 - protein kinase binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 696
+	Hs
		1317646 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		RHBT2_HUMAN (1-690): 2.28e-168: 502: 67.94
+	Hs
		227024 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CDC42_HUMAN (12-218): 1.55e-89: 279: 37.14
+	Hs
		227111 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RAC1_HUMAN (12-219): 7.28e-73: 235: 35.55
+	Hs
		227019 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RAC3_HUMAN (12-208): 1.21e-70: 230: 39.50
+	Hs
		227168 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RHOG_HUMAN (12-210): 1.67e-69: 226: 36.63
+	Hs
		228651 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RAB1B_HUMAN (1-249): 4.91e-69: 226: 18.25
+	Hs
		214429 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		SPOP_HUMAN (300-648): 8.45e-74: 244: 15.32
+	Hs
		918975 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		RAB1A_HUMAN (1-239): 4.59e-72: 234: 16.94
+	Ce
		975578 Q9XUS3_CAEEL (6-464): 2.19e-70: 230: 25.44		RAC1_CAEEL (12-218): 2.78e-72: 234: 37.62
+	Sc
		350834 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		YPT1_YEAST (8-238): 1.29e-70: 230: 19.23
+	Hs
		474987 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		RAC1_HUMAN (12-219): 7.28e-73: 235: 35.55
+	Hs
		475548 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CDC42_HUMAN (12-218): 1.55e-89: 279: 37.14
+	Hs
		476494 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		IBTK_HUMAN (208-637): 7.17e-71: 253: 14.77
+	Hs
		475593 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RAC1_HUMAN (12-219): 7.28e-73: 235: 35.55
+	At
		656930 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		RAD2A_ARATH (8-242): 4.2e-73: 237: 17.23
+	Zm
		24708 A0A1D6IJX7_MAIZE (233-459): 1.19e-26: 116: 21.70		B4FNJ6_MAIZE (10-242): 7.7e-73: 236: 17.37
+	Hs
		475625 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RHOG_HUMAN (12-210): 1.67e-69: 226: 36.63
+	Hs
		475558 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RHOA_HUMAN (16-215): 2.02e-68: 224: 36.45