HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: UBXN7 (O94888)
UBX domain-containing protein 7
Gene: UBXN7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35987950
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UBA_4~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0043130 - ubiquitin binding GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 489
+	Hs
		228306 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FAF2_HUMAN (1-487): 5.33e-86: 273: 17.03
+	Hs
		299309 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		UBXN7_HUMAN (1-489): 5.1e-157: 456: 100.00
+	Hs
		229064 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FAF1_HUMAN (115-488): 8.56e-73: 244: 16.01
+	Hs
		299310 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UBXN7_HUMAN (1-489): 5.1e-157: 456: 100.00
+	Hs
		227228 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		UBXN1_HUMAN (231-488): 9.67e-29: 117: 16.23
+	Hs
		475128 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		FAF2_HUMAN (1-487): 5.33e-86: 273: 17.03
+	Hs
		475246 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		FAF1_HUMAN (115-488): 8.56e-73: 244: 16.01
+	Hs
		476174 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		FAF2_HUMAN (1-487): 5.33e-86: 273: 17.03
+	Sc
		477464 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		UBX5_YEAST (14-321): 8.41e-55: 192: 25.13
+	Hs
		476571 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		FAF1_HUMAN (115-488): 8.56e-73: 244: 16.01
+	Hs
		475650 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UBXN1_HUMAN (231-488): 9.67e-29: 117: 16.23