HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PRP6 (O94906)
Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein)
Gene: PRPF6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	35509820, 35256949, 24244333
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0016607 - nuclear speck GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 941
+	Dm
		1180619 PRKN_DROME (1-463): 3.5e-106: 325: 42.19		Q7KJA9_DROME (191-711): 2.56e-67: 246: 12.66
+	Hs
		228611 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CRNL1_HUMAN (521-932): 8.54e-41: 164: 12.50
+	Hs
		227803 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CTR9_HUMAN (126-536): 3.3e-16: 85.7: 10.12
+	Hs
		228770 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SYF1_HUMAN (109-527): 1.77e-12: 73.4: 13.78
+	Dm
		284375 ARI2_DROME (228-464): 7.29e-69: 229: 20.92		Q7KJA9_DROME (191-711): 2.56e-67: 246: 12.66
+	Hs
		174471 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		OGT1_HUMAN (120-352): 4.99e-10: 65.7: 11.39
+	Hs
		174509 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		OGT1_HUMAN (120-352): 4.99e-10: 65.7: 11.39
+	Hs
		476163 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TTC28_HUMAN (441-940): 3.1e-38: 157: 7.45
+	Hs
		174570 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		OGT1_HUMAN (120-352): 4.99e-10: 65.7: 11.39
+	At
		97250 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		RRP5_ARATH (298-492): 7.56e-10: 65.2: 15.67