HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

The method score is based on:

Property	Details
Experiments	28395174, 35509820, 35987950, 35256949
Identification Methods	pull down, enzymatic study, affinity chromatography technology, proximity labelling technology
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000423 - mitophagy GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion and 12 others more... GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol GO:0008270 - zinc ion binding GO:0010628 - positive regulation of gene expression GO:0019899 - enzyme binding GO:0031625 - ubiquitin protein ligase binding GO:0042826 - histone deacetylase binding GO:0042981 - regulation of apoptotic process GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0050821 - protein stabilization GO:0051087 - protein-folding chaperone binding GO:2000378 - negative regulation of reactive oxygen species metabolic process
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1	465
Hs

1	393

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024