HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: NPM (P06748)
Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)
Gene: NPM1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	25959826, 32929329, 35256949, 24244333
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 294
+	Hs
		312448 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		NPM_HUMAN (1-294): 1.47e-143: 407: 100.00
+	Hs
		417869 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		NPM_HUMAN (1-294): 1.47e-143: 407: 100.00
+	Hs
		417870 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		NPM_HUMAN (1-294): 1.47e-143: 407: 100.00