HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: LDHB (P07195)
L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46)
Gene: LDHB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	25959826, 32929329, 35509820, 35256949
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0019900 - kinase binding
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 334
+	Hs
		226188 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LDHA_HUMAN (1-332): 3.36e-160: 452: 75.60
+	Hs
		227825 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LDH6A_HUMAN (1-332): 4.92e-153: 434: 65.36
+	Hs
		226289 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LDHC_HUMAN (1-331): 1.03e-151: 430: 69.79
+	Hs
		228602 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LDH6B_HUMAN (1-332): 5.85e-150: 428: 66.87
+	Hs
		227988 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		UEVLD_HUMAN (22-332): 2.48e-102: 310: 39.81
+	Hs
		226737 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MDHC_HUMAN (23-329): 4.71e-98: 294: 20.87
+	Hs
		226738 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MDHM_HUMAN (11-334): 3.52e-96: 290: 18.92
+	Hs
		421950 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		LDHB_HUMAN (1-334): 5.62e-161: 454: 100.00
+	Hs
		334112 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		LDHA_HUMAN (1-332): 3.36e-160: 452: 75.60
+	Hs
		1220110 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		UEVLD_HUMAN (22-332): 2.48e-102: 310: 39.81
+	At
		1092443 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		MDHM1_ARATH (2-332): 4.51e-112: 330: 21.41
+	At
		1092136 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		MDHM2_ARATH (2-332): 5.1e-110: 325: 21.11
+	Hs
		476026 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UEVLD_HUMAN (22-332): 2.48e-102: 310: 39.81
+	At
		1092365 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		MDHP_ARATH (21-331): 1.58e-101: 306: 21.05