HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PFKAM (P08237)
ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase)
Gene: PFKM

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0019900 - kinase binding GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 780
+	Hs
		227202 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PFKAP_HUMAN (5-771): 0: 1028: 71.75
+	Hs
		437707 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PFKAM_HUMAN (1-780): 0: 1079: 100.00
+	Hs
		475642 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PFKAP_HUMAN (5-771): 0: 1028: 71.75
+	Hs
		226463 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PFKAL_HUMAN (6-355): 8.8e-78: 268: 29.51
+	At
		1092044 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PFKA4_ARATH (17-379): 9.58e-120: 372: 19.95
+	At
		1091842 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PFKA5_ARATH (17-379): 9.72e-111: 349: 22.08
+	At
		1091983 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PFPA2_ARATH (11-269): 3.42e-77: 262: 17.84
+	At
		1091863 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PFPB1_ARATH (7-290): 2.87e-77: 261: 19.67
+	At
		1092411 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PFPA1_ARATH (11-267): 7.71e-73: 251: 16.11