HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: DLDH (P09622)
Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein)
Gene: DLD

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005739 - mitochondrion
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 509
+	Mm
		139803 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		DLDH_MOUSE (1-509): 0: 537: 94.89
+	Hs
		226192 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GSHR_HUMAN (1-498): 2.44e-139: 413: 25.47
+	Hs
		227605 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TRXR1_HUMAN (58-507): 9.5e-132: 398: 27.81
+	Sc
		452936 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		DLDH_YEAST (10-508): 4.36e-154: 450: 52.77
+	At
		1092243 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		DLDH1_ARATH (1-508): 2.26e-166: 481: 54.92
+	Hs
		475837 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TRXR1_HUMAN (58-507): 9.5e-132: 398: 27.81
+	At
		67653 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PLPD1_ARATH (12-503): 5.21e-126: 382: 32.61
+	At
		97840 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PLPD2_ARATH (59-506): 2.7e-121: 368: 32.25
+	At
		186685 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		TRXB3_ARATH (13-461): 3.78e-69: 232: 16.85