HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.989

Property	Details
Experiments	25474007, 25847540, 34642328, 35491809, 23670163, 26254304, 26162776, 25969509, 26116755, 28414322, 28319114, 27284007, 30446597, 25959826, 35509820, 35690145, 23861750, 22724072, 24751536, 24784582
Identification Methods	pull down, affinity chromatography technology, x-ray crystallography, enzymatic study, fluorescent resonance energy transfer
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	ubiquitin~ubiquitin, ubiquitin~zf-RING_12, ubiquitin~zf-RING_14
Common GO terms	GO:0005634 - nucleus GO:0005741 - mitochondrial outer membrane GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 685
+	Hs
		476630 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476320 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		312458 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476496 AKIB1_HUMAN (238-456): 1.26e-60: 215: 21.55		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475939 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		UBC_HUMAN (1-685): 0: 846: 100.00
+	Dm
		477528 LUBEL_DROME (55-453): 1.14e-66: 234: 16.95		UBIQP_DROME (1-610): 0: 752: 99.84
+	Bt
		477667 UBC_BOVIN (1-149): 6.08e-49: 179: 19.33		UBC_BOVIN (1-613): 0: 753: 99.18
+	Dm
		1214032 LUBEL_DROME (55-453): 1.14e-66: 234: 16.95		Q9W418_DROME (229-685): 0: 557: 99.78
+	At
		96040 F4I9X6_ARATH (1-159): 9.58e-47: 166: 18.41		UBQ10_ARATH (305-685): 2.63e-153: 453: 95.80
+	Hs
		227107 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Rn
		1144287 PRKN_RAT (1-465): 2.14e-136: 402: 85.16		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Sc
		477225 HEL1_YEAST (204-463): 2e-41: 156: 19.78		UBI4P_YEAST (381-685): 5e-122: 370: 95.74
+	Hs
		226251 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69
+	Hs
		171468 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		UBD_HUMAN (155-304): 5.41e-28: 112: 32.05
+	Hs
		226334 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Hs
		475094 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Mm
		477054 HOIL1_MOUSE (12-448): 2.29e-67: 225: 17.50		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		312457 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Hs
		475069 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Hs
		474899 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70