HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: BCL2 (P10415)
Apoptosis regulator Bcl-2
Gene: BCL2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

The method score is based on:

Property	Details
Experiments	32929329, 20889974
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane and 7 others more... GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0031647 - regulation of protein stability GO:0043524 - negative regulation of neuron apoptotic process GO:0051881 - regulation of mitochondrial membrane potential GO:2000378 - negative regulation of reactive oxygen species metabolic process
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	465
Hs

1	239

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024