HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: THIO (P10599)
Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP) (allergen Hom s Trx)
Gene: TXN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	25959826, 32929329, 35256949, 24244333
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043388 - positive regulation of DNA binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 105
+	Hs
		228073 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TXND5_HUMAN (12-105): 2.13e-27: 105: 27.00
+	Hs
		226398 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PDIA4_HUMAN (3-104): 4.21e-25: 99.4: 23.85
+	Hs
		226279 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PDIA1_HUMAN (2-103): 7.44e-23: 92.9: 22.22
+	Hs
		227756 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TXND8_HUMAN (1-105): 4.15e-25: 92.8: 42.52
+	Zm
		43114 A0A1D6PFP9_MAIZE (202-461): 2.58e-61: 214: 23.16		Q8H6X5_MAIZE (2-101): 1.75e-34: 116: 39.22
+	Hs
		202582 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TXNL1_HUMAN (2-105): 1.99e-36: 126: 40.39
+	At
		221312 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		TRXM1_ARATH (3-105): 3.7e-37: 125: 31.43
+	At
		1091672 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		TRXH3_ARATH (2-104): 7.63e-34: 114: 39.05
+	At
		1092431 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		TRXF2_ARATH (2-102): 9.29e-33: 114: 40.20