HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: KAP0 (P10644)
cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1)
Gene: PRKAR1A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010629 - negative regulation of gene expression GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 381
+	Hs
		475273 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00
+	Hs
		475386 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		KAP1_HUMAN (1-381): 1.35e-138: 401: 81.37
+	Hs
		226406 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KAP2_HUMAN (233-379): 1.21e-17: 85.5: 26.53
+	Hs
		228001 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PLPL6_HUMAN (249-378): 1.38e-10: 65.1: 14.60
+	Hs
		1172936 RNF14_HUMAN (161-464): 6.69e-69: 229: 21.56		PLPL7_HUMAN (249-378): 4.85e-10: 63.5: 18.25
+	Sc
		477444 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		NTE1_YEAST (152-253): 1.22e-12: 71.6: 21.19
+	Hs
		476030 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PLPL6_HUMAN (249-378): 1.38e-10: 65.1: 14.60