HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: ERR1 (P11474)
Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)
Gene: ESRRA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21177257
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0008270 - zinc ion binding GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 423
+	Hs
		227082 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ERR3_HUMAN (25-422): 2.3e-119: 357: 59.30
+	Hs
		226161 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ERR2_HUMAN (3-422): 1.9e-116: 348: 56.10
+	Hs
		226343 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		COT1_HUMAN (30-418): 1.09e-111: 336: 29.67
+	Hs
		370369 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86
+	Hs
		368862 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86
+	Hs
		611519 AKIB1_HUMAN (238-456): 1.26e-60: 215: 21.55		NR4A1_HUMAN (3-422): 2.87e-104: 322: 29.95
+	Hs
		475269 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		COT1_HUMAN (30-418): 1.09e-111: 336: 29.67
+	Dm
		1373593 Q9W418_DROME (1-77): 5.42e-30: 124: 32.47		Q9VSE9_DROME (76-421): 7.3e-81: 258: 42.86