HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PYC (P11498)
Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB)
Gene: PC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0010629 - negative regulation of gene expression
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 1178
+	Hs
		475285 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PYC_HUMAN (1-1178): 0: 1462: 100.00
+	Hs
		227322 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ACACA_HUMAN (1-746): 1.06e-175: 573: 22.40
+	Hs
		475692 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ACACA_HUMAN (1-746): 1.06e-175: 573: 22.40
+	At
		1091640 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		ACC1_ARATH (15-763): 1.33e-175: 572: 22.22
+	At
		95494 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		ACC2_ARATH (19-763): 3.63e-175: 572: 23.06
+	Hs
		226587 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PYR1_HUMAN (19-420): 1.96e-55: 214: 16.07
+	At
		138699 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		ACCC_ARATH (38-503): 1.05e-160: 490: 43.56
+	Hs
		226252 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PCCA_HUMAN (1065-1178): 1.27e-34: 144: 30.44
+	Hs
		228431 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MCCA_HUMAN (1085-1178): 3.52e-27: 121: 29.00
+	Sc
		424289 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		PYR1_YEAST (19-420): 2.78e-58: 223: 16.83
+	Hs
		398217 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PCCA_HUMAN (1065-1178): 1.27e-34: 144: 30.44
+	Hs
		476238 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MCCA_HUMAN (1085-1178): 3.52e-27: 121: 29.00
+	At
		1091678 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		MCCA_ARATH (1087-1178): 1.94e-25: 115: 30.44