HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PCNA (P12004)
Proliferating cell nuclear antigen (PCNA) (Cyclin)
Gene: PCNA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.906

Property	Details
Experiments	28430587, 32929329, 35509820, 35256949, 19285961
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PCNA_C~ubiquitin
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0019899 - enzyme binding GO:0044877 - protein-containing complex binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 261
+	Xl
		1161301 Q7SY79_XENLA (1-149): 2.25e-49: 179: 19.33		Q6PF20_XENLA (1-261): 2.46e-122: 350: 89.66
+	Sc
		477104 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		PCNA_YEAST (1-259): 1.46e-99: 293: 35.52
+	Hs
		475289 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00
+	Hs
		475913 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		Q6FI35_HUMAN (1-261): 7.29e-125: 357: 99.62
+	At
		1092244 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PCNA1_ARATH (1-261): 8.59e-119: 342: 64.75
+	At
		1092482 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PCNA2_ARATH (1-261): 1.41e-118: 341: 65.52
+	Sp
		477569 UBI4P_SCHPO (1-76): 1.1e-29: 121: 31.58		PCNA_SCHPO (1-259): 1.09e-108: 316: 50.97