HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: ADT3 (P12236)
ADP/ATP translocase 3 (ADP,ATP carrier protein 3) (ADP,ATP carrier protein, isoform T2) (ANT 2) (Adenine nucleotide translocator 3) (ANT 3) (Solute carrier family 25 member 6) [Cleaved into: ADP/ATP translocase 3, N-terminally processed]
Gene: SLC25A6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	32929329, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005739 - mitochondrion
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 298
+	Hs
		226250 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ADT2_HUMAN (1-297): 8.7e-111: 324: 92.26
+	Hs
		226378 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ADT1_HUMAN (1-298): 6.2e-111: 324: 88.26
+	Hs
		227774 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SCMC2_HUMAN (3-199): 3.97e-45: 160: 23.35
+	Hs
		229010 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		S2513_HUMAN (3-271): 4.13e-43: 158: 18.96
+	Hs
		226076 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		S2512_HUMAN (12-119): 3.18e-19: 89.5: 22.02
+	Hs
		227780 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SCMC1_HUMAN (204-298): 4.9e-16: 79.8: 15.63
+	Hs
		1317097 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		S2513_HUMAN (3-271): 4.13e-43: 158: 18.96
+	Hs
		476538 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		S2513_HUMAN (3-271): 4.13e-43: 158: 18.96
+	At
		778356 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		ADT2_ARATH (204-297): 6.22e-12: 67.2: 23.47
+	At
		221617 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		ADT3_ARATH (7-108): 7.08e-10: 61: 24.51