HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: NDKA (P15531)
Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein)
Gene: NME1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35987950, 35256949
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042981 - regulation of apoptotic process GO:0043388 - positive regulation of DNA binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 152
+	Hs
		226526 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NDKB_HUMAN (1-152): 4.45e-92: 265: 88.16
+	Hs
		226052 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NDK6_HUMAN (4-134): 1.5e-52: 166: 30.37
+	Hs
		229180 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NDK7_HUMAN (7-135): 2.35e-39: 138: 28.57
+	Hs
		474922 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		NDKB_HUMAN (1-152): 4.45e-92: 265: 88.16
+	Hs
		475016 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		NDK3_HUMAN (5-152): 3.29e-83: 243: 67.57
+	At
		221500 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		NDK3_ARATH (2-151): 4.17e-83: 245: 62.00
+	At
		249504 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		NDK2_ARATH (1-152): 2.22e-79: 236: 53.95
+	At
		761634 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		NDK1_ARATH (4-152): 2.05e-80: 235: 62.42