HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PGAM1 (P18669)
Phosphoglycerate mutase 1 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 1) (Phosphoglycerate mutase isozyme B) (PGAM-B)
Gene: PGAM1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	25959826, 32929329, 35987950, 35256949
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 254
+	Hs
		227603 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		F264_HUMAN (1-246): 4.55e-62: 203: 20.73
+	Hs
		226015 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		F262_HUMAN (1-253): 2.33e-60: 200: 19.37
+	Hs
		227602 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		F263_HUMAN (1-239): 1.29e-57: 193: 20.50
+	Hs
		228790 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TIGAR_HUMAN (1-230): 5.26e-44: 151: 20.85
+	Sc
		343501 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		PMG1_YEAST (4-252): 2.14e-94: 279: 50.20
+	Hs
		241700 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		F262_HUMAN (1-253): 2.33e-60: 200: 19.37
+	Hs
		475305 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PGAM2_HUMAN (1-253): 1.05e-118: 340: 81.03
+	Hs
		241674 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		F262_HUMAN (1-253): 2.33e-60: 200: 19.37