HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: NUCL (P19338)
Nucleolin (Protein C23)
Gene: NCL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	25959826, 35509820, 35256949
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 710
+	Hs
		228318 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP5_HUMAN (233-555): 7.34e-51: 183: 17.20
+	Hs
		226375 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55
+	Hs
		228678 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP3_HUMAN (221-482): 6.38e-43: 166: 16.20
+	Hs
		227354 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP4_HUMAN (222-488): 1.86e-42: 165: 14.88
+	Hs
		312474 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		NUCL_HUMAN (1-650): 8.84e-98: 318: 100.00
+	Hs
		227642 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PAP1L_HUMAN (569-655): 2.88e-17: 87.7: 25.56
+	Hs
		475325 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		NUCL_HUMAN (1-650): 8.84e-98: 318: 100.00
+	Hs
		1031383 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		PABP4_HUMAN (222-488): 1.86e-42: 165: 14.88
+	Hs
		312462 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55
+	Hs
		475288 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55
+	Hs
		475708 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PABP4_HUMAN (222-488): 1.86e-42: 165: 14.88
+	At
		186465 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PABP4_ARATH (224-483): 2.58e-37: 150: 19.93
+	At
		983451 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PABP5_ARATH (202-404): 2.71e-20: 97.8: 13.36